CALR-positive essential thrombocythaemia preceded by immune thrombocytopaenia

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dc.contributor.authorBarrett, A.
dc.contributor.authorCahill, Mary R.
dc.date.accessioned2021-07-23T09:48:21Z
dc.date.available2021-07-23T09:48:21Z
dc.date.issued2021
dc.date.updated2021-07-23T09:42:50Z
dc.description.abstractPresentation: The patient initially presented with gum bleeding and a petechial rash. Diagnosis: The patient was found to be severely thrombocytopaenic and bone marrow biopsy showed a marked excess of megakaryocytes consistent with a diagnosis of immune thrombocytopaenia (ITP). She underwent splenectomy. Seven years following splenectomy, her platelet count began to rise again, and repeat bone marrow sampling revealed an increase in megakaryocytes with evidence of clustering. On further testing the calreticulin (CALR) exon 9 variant was found and a diagnosis of essential thrombocythaemia (ET) was made. Treatment: Thromboprophylaxis and cytoreductive therapy (hydroxyurea) were initiated following ET diagnosis. Discussion: Possible mechanisms of ET (platelet excess) following ITP (platelet deficiency) include the known associations of autoimmune conditions and malignancy and the effects of immunosuppression and splenectomy in tumorigenesis. To our knowledge, this is the first recorded case of ITP preceding later development of CALR- positive ET.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidP338en
dc.identifier.citationBarrett, A. and Cahill, M. R. (2021) 'CALR-positive essential thrombocythaemia preceded by immune thrombocytopaenia', Irish Medical Journal, 114(4), P338 (4pp). Available at: http://imj.ie/calr-positive-essential-thrombocythaemia-preceded-by-immune-thrombocytopaenia/ (Accessed: 23 July 2021)en
dc.identifier.endpage4en
dc.identifier.issn0332-3102
dc.identifier.issued4en
dc.identifier.journaltitleIrish Medical Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11588
dc.identifier.volume114en
dc.language.isoenen
dc.publisherIrish Medical Organisationen
dc.relation.urihttp://imj.ie/calr-positive-essential-thrombocythaemia-preceded-by-immune-thrombocytopaenia/
dc.relation.urihttps://imj.ie/irish-medical-journal-april-2021-vol-114-no-4/
dc.rights© 2021, Irish Medical Journal. All rights reserved.en
dc.subjectImmune thrombocytopaeniaen
dc.subjectITPen
dc.subjectEssential thrombocythaemiaen
dc.subjectETen
dc.titleCALR-positive essential thrombocythaemia preceded by immune thrombocytopaeniaen
dc.typeArticle (peer-reviewed)en
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