Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.

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dc.contributor.authorO'Connor, Owen J.
dc.contributor.authorVandeleur, Moya
dc.contributor.authorMcGarrigle, Anne Marie
dc.contributor.authorMoore, Niamh
dc.contributor.authorMcWilliams, Sebastian R.
dc.contributor.authorMcSweeney, Seán E.
dc.contributor.authorO'Neill, Michael
dc.contributor.authorNí Chróinín, Muireann
dc.contributor.authorMaher, Michael M.
dc.date.accessioned2018-08-22T14:24:35Z
dc.date.available2018-08-22T14:24:35Z
dc.date.issued2010-12-01
dc.date.updated2018-06-20T16:31:44Z
dc.description.abstractPurpose: To develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography. Materials and Methods: After institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5–25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30–50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator. Results: Low-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0–19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88–0.92; P < .001). Conclusion: Low-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO’Connor, O. J., Vandeleur, M., McGarrigle, A. M., Moore, N., McWilliams, S. R., McSweeney, S. E., O’Neill, M., Chroinin, M. N. and Maher, M. M. (2010) 'Development of Low-Dose Protocols for Thin-Section CT Assessment of Cystic Fibrosis in Pediatric Patients', Radiology, 257(3), pp. 820-829. doi:10.1148/radiol.10100278en
dc.identifier.doi10.1148/radiol.10100278
dc.identifier.endpage829en
dc.identifier.issn0033-8419
dc.identifier.issn1527-1315
dc.identifier.issued3en
dc.identifier.journaltitleRadiologyen
dc.identifier.startpage820en
dc.identifier.urihttps://hdl.handle.net/10468/6635
dc.identifier.volume257en
dc.language.isoenen
dc.publisherRadiological Society of North America (RSNA)en
dc.relation.urihttps://pubs.rsna.org/doi/abs/10.1148/radiol.10100278
dc.rights© RSNA, 2010. Note: This copy is for your personal, non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact www.rsna.org/rsnarights.en
dc.subjectCystic fibrosisen
dc.subjectProspective studiesen
dc.subjectRadiation dosageen
dc.subjectRadiography, thoracicen
dc.subjectStatistics, nonparametricen
dc.subjectTomography, x-Ray computeden
dc.subjectComputer assisted tomographyen
dc.subjectCystic fibrosisen
dc.subjectDiagnostic valueen
dc.subjectDisease severityen
dc.subjectDosimetryen
dc.subjectImage analysisen
dc.subjectImage qualityen
dc.subjectLow energy radiationen
dc.subjectLung structureen
dc.subjectThorax radiographyen
dc.titleDevelopment of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.en
dc.typeArticle (peer-reviewed)en
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