World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunction

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dc.contributor.authorSimms, Melanie Louiseen
dc.contributor.authorKuten-Shorrer, Michalen
dc.contributor.authorWiriyakijja, Paswachen
dc.contributor.authorNiklander, Sven Ericen
dc.contributor.authorSantos-Silva, Alan Rogeren
dc.contributor.authorSankar, Vidyaen
dc.contributor.authorKerr, Alexander Rossen
dc.contributor.authorBeier Jensen, Sirien
dc.contributor.authorNi Riordain, Richealen
dc.contributor.authorDelli, Konstantinaen
dc.contributor.authorVilla, Alessandroen
dc.contributor.funderAmerican Academy of Oral Medicineen
dc.contributor.funderEuropean Association of Oral Medicineen
dc.contributor.funderChurch and Dwighten
dc.contributor.funderColgate-Palmolive Companyen
dc.date.accessioned2024-08-21T13:46:26Z
dc.date.available2024-08-21T13:46:26Z
dc.date.issued2023-03-02en
dc.description.abstractObjective: To identify all outcome measures used to assess salivary gland hypofunction (i.e., objective measures used to determine actual changes in saliva quantity or to assess response to treatment of salivary gland hypofunction) and to group these into domains. Study Design: A systematic review including clinical trials and prospective or retrospective observational studies involving human participants with dry mouth, with any type of intervention where the objective assessment of salivary gland hypofunction was described. Results: Five hundred fifty-three studies involving 31,507 participants were identified. Most assessed salivary gland hypofunction and xerostomia (68.7%), whereas 31.3% assessed salivary gland hypofunction alone. Most studies investigated the “amount of saliva,” and the highest number of outcome measures were within the domain of “clinical/objective signs of salivary gland hypofunction.” Conclusions: Seven domains encompassing 30 outcome measures were identified, confirming the diversity in outcomes and outcome measures used in research regarding salivary gland hypofunction. Identified items will be used in conjunction with those identified regarding xerostomia to create a core outcome set for dry mouth quantification for use in future clinical trials, with the overall goal of improving the standardization of reporting, leading to the establishment of more robust evidence for the management of dry mouth and improving patient care.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSimms, M. L., Kuten-Shorrer, M., Wiriyakijja, P., Niklander, S. E., Santos-Silva, A. R., Sankar, V., Kerr, A. R., Jensen, S. B., Ni Riordain, R., Delli, K. and Villa, A. (2023) 'World Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunction', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 135(6), pp.804-826. https://doi.org/10.1016/j.oooo.2022.12.018en
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2022.12.018en
dc.identifier.endpage826en
dc.identifier.issn2212-4403en
dc.identifier.issued6en
dc.identifier.journaltitleOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyen
dc.identifier.startpage804en
dc.identifier.urihttps://hdl.handle.net/10468/16219
dc.identifier.volume135en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2023, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectDry mouthen
dc.subjectSalivary gland hypofunctionen
dc.subjectHyposalivationen
dc.subjectXerostomiaen
dc.subjectOutcome domainsen
dc.subjectOutcome measuresen
dc.titleWorld Workshop on Oral Medicine VIII: Development of a core outcome set for dry mouth: a systematic review of outcome domains for salivary hypofunctionen
dc.typeArticle (peer-reviewed)en
oaire.citation.issue6en
oaire.citation.volume135en
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