Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide

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dc.check.date2019-03-17
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorHenze, Laura J.
dc.contributor.authorGriffin, Brendan T.
dc.contributor.authorChristiansen, Martin
dc.contributor.authorBundgaard, Christoffer
dc.contributor.authorLangguth, Peter
dc.contributor.authorHolm, René
dc.contributor.funderHorizon 2020en
dc.date.accessioned2018-03-27T11:17:39Z
dc.date.available2018-03-27T11:17:39Z
dc.date.issued2018-03-17
dc.date.updated2018-03-27T11:10:52Z
dc.description.abstractThe present study investigated the gastric emptying rate in Göttingen minipigs pre- and post-prandial and evaluated the effect of metoclopramide on the same parameter, using paracetamol as an absorption marker. The pharmacokinetic evaluation of the obtained plasma concentration data for paracetamol demonstrated that the fastest gastric emptying rate was observed in the animals that were allowed access to normal pig food. There was no significant difference in the stomach emptying rate observed between fasted and fed minipigs, when fed either with a FDA standard breakfast or a nutritional energy drink. Pre-dosing minipigs with metoclopramide (0.2 or 0.4 mg/kg) did not demonstrate any effect on gastric emptying in either the fasted or fed state. The data in the present study demonstrated a relatively prolonged gastric emptying rate in mini-pigs both in the fasted and fed state, hence when conducting pharmacokinetic studies using mini-pigs, this should be taken into account in planning the plasma sampling time points. Further, as no difference could be observe in gastric emptying rate as a function of food the data also suggest that the Göttingen minipigs seems less suited to predict for food effect studies than other species.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHenze, L. J., Griffin, B. T., Christiansen, M., Bundgaard, C., Langguth, P. and Holm, R. (2018) 'Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide', European Journal of Pharmaceutical Sciences, In Press. doi: 10.1016/j.ejps.2018.03.017en
dc.identifier.doi10.1016/j.ejps.2018.03.017
dc.identifier.endpage32en
dc.identifier.issn0928-0987
dc.identifier.journaltitleEuropean Journal of Pharmaceutical Sciencesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/5697
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/674909/EU/Pharmaceutical Education And Research with Regulatory Links: Innovative drug development strategies and regulatory tools tailored to facilitate earlier access to medicines/PEARRLen
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0928098718301325
dc.rights© 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGastric emptyingen
dc.subjectMini-pigsen
dc.subjectMetoclopramideen
dc.subjectFasted stateen
dc.subjectFed stateen
dc.titleExploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramideen
dc.typeArticle (peer-reviewed)en
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