Polydopamine nanoparticles for treatment of acute inflammation-induced injury

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dc.check.date2019-03-13
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorZhao, He
dc.contributor.authorZeng, Zhandong
dc.contributor.authorLiu, Lin
dc.contributor.authorChen, Jiawen
dc.contributor.authorZhou, Huiting
dc.contributor.authorHuang, Lili
dc.contributor.authorHuang, Jie
dc.contributor.authorXu, Hua
dc.contributor.authorXu, Yunyun
dc.contributor.authorChen, Zhengrong
dc.contributor.authorWu, Yi
dc.contributor.authorGuo, Wanliang
dc.contributor.authorWang, Jiang Huai
dc.contributor.authorWang, Jian
dc.contributor.authorLiu, Zhuang
dc.contributor.funderMinistry of Science and Technology of the People's Republic of Chinaen
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderNatural Science Foundation of Jiangsu Provinceen
dc.contributor.funderSuzhou Municipal Science and Technology Project, China
dc.contributor.funderKey Laboratory of Suzhou, China
dc.contributor.funderSuzhou Clinical Medicine Center, China
dc.contributor.funderJiangsu Natural Science Fund for Distinguished Young Scholars
dc.contributor.funderJiangsu Higher Education Institutions, China
dc.contributor.funderCollaborative Innovation Center of Suzhou Nano Science and Technology, China
dc.date.accessioned2018-03-27T08:59:15Z
dc.date.available2018-03-27T08:59:15Z
dc.date.issued2018-03-13
dc.date.updated2018-03-21T12:03:11Z
dc.description.abstractNanotechnology-mediated anti-inflammatory therapy is emerging as a novel strategy for treatment of inflammation-induced injury. However, one of the main hurdles for these anti-inflammatory nano-drugs is their potential toxic side effects in vivo. Herein, we uncovered that polydopamine (PDA) nanoparticles with structure and chemical properties similar to melanin, a natural bio-polymer, displayed significant anti-inflammation therapeutic effect on acute inflammation-induced injury. PDA with enriched phenol groups functioned as a radical scavenger to eliminate reactive oxygen species (ROS) generated during inflammatory responses. As revealed by in vivo photoacoustic imaging with a H2O2-specific nanoprobe, PDA nanoparticles remarkably reduced intracellular ROS levels in murine macrophages challenged with either H2O2 or lipopolysaccharide (LPS). The anti-inflammatory capacity of PDA nanoparticles was further demonstrated in murine models of both acute peritonitis and acute lung injury (ALI), where diminished ROS generation, reduced proinflammatory cytokines, attenuated neutrophil infiltration, and alleviated lung tissue damage were observed in PDA-treated mice after a single dose of PDA treatment. Our work therefore presents the great promise of PDA nanoparticles as a biocompatible nano-drug for anti-inflammation therapy to treat acute inflammation-induced injury.en
dc.description.sponsorshipMinistry of Science and Technology of the People´s Republic of China (National Basic Research Programs of China - 973Program (2016YFA0201200)); National Natural Science Foundation of China (81602181, 81501703, 81500733, 81502500, 81420108022, 81272143, 51525203, 31300824, 81701948); Natural Science Foundation of Jiangsu Province (BK20150292, 20150293, 20150294); Suzhou Municipal Science and Technology Project (SYS201565, SYS201759); Key Laboratory of Suzhou (SZS201307); Suzhou Clinical Medicine Center (Szzxj201505); Jiangsu Natural Science Fund for Distinguished Young Scholars (BK20130005); Jiangsu Higher Education Institutions (Priority Academic Program Development)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationZhao, H., Zeng, Z., Liu, L., Chen, J., Zhou, H., Huang, L., Huang, J., Xu, H., Xu, Y., Chen, Z., Wu, Y., Guo, W., Wang, J. H., Wang, J. and Liu, Z. (2018) 'Polydopamine nanoparticles for treatment of acute inflammation-induced injury', Nanoscale. doi:10.1039/C8NR00838Hen
dc.identifier.doi10.1039/C8NR00838H
dc.identifier.issn2040-3364
dc.identifier.journaltitleNanoscaleen
dc.identifier.urihttps://hdl.handle.net/10468/5695
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.rights© 2018, the Authors. Published by the Royal Society of Chemistry. All rights reserved. This document is the accepted version of an article published in final form in Nanoscale. To access the final published work see http://dx.doi.org/10.1039/C8NR00838Hen
dc.subjectPolydopamineen
dc.subjectAcute inflammation injuryen
dc.subjectReactive oxygen speciesen
dc.subjectAnti-inflammation therapyen
dc.titlePolydopamine nanoparticles for treatment of acute inflammation-induced injuryen
dc.typeArticle (peer-reviewed)en
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