Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids
| dc.contributor.author | Deasy, Rebecca E. | |
| dc.contributor.author | Brossat, Maude | |
| dc.contributor.author | Moody, Thomas S. | |
| dc.contributor.author | Maguire, Anita R. | |
| dc.contributor.funder | Irish Research Council for Science Engineering and Technology | en |
| dc.contributor.funder | Eli Lilly and Company, United States | en |
| dc.date.accessioned | 2012-05-02T15:33:23Z | |
| dc.date.available | 2012-05-02T15:33:23Z | |
| dc.date.copyright | 2011 | |
| dc.date.issued | 2011-02-02 | |
| dc.description.abstract | Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) is described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation was also explored. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Accepted Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | DEASY, R. E., BROSSAT, M., MOODY, T. S. & MAGUIRE, A. R. 2011. Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids. Tetrahedron: Asymmetry, 22, 47-61. doi: 10.1016/j.tetasy.2010.12.019 | en |
| dc.identifier.doi | 10.1016/j.tetasy.2010.12.019 | |
| dc.identifier.endpage | 61 | en |
| dc.identifier.issn | 0957-4166 | |
| dc.identifier.issued | 1 | en |
| dc.identifier.journaltitle | Tetrahedron: Asymmetry | en |
| dc.identifier.startpage | 47 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/575 | |
| dc.identifier.volume | 22 | en |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.relation.uri | http://www.sciencedirect.com/science/article/pii/S0957416610008608 | |
| dc.rights | © 2011 Elsevier Ltd. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in Tetrahedron: Asymmetry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron: Asymmetry, [22, 1,(02/02/2011)] 10.1016/j.tetasy.2010.12.019 | en |
| dc.subject | 3-aryl | en |
| dc.subject | Alkanoic acid | en |
| dc.subject | Hydrolase catalysed | en |
| dc.subject | Enantiopurity | en |
| dc.title | Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids | en |
| dc.type | Article (peer-reviewed) | en |
