The presentation and diagnosis of the first known community transmitted case of SARS-CoV-2 in the Republic of Ireland

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dc.contributor.authorFaller, Eamonn
dc.contributor.authorLapthorne, S.
dc.contributor.authorBarry, R.
dc.contributor.authorShamile, F.
dc.contributor.authorSalleh, F.
dc.contributor.authorDoyle, D.
dc.contributor.authorO'Halloran, D.
dc.contributor.authorPrentice, Michael B.
dc.date.accessioned2020-11-30T12:52:43Z
dc.date.available2020-11-30T12:52:43Z
dc.date.issued2020
dc.description.abstractIntroduction: This case series describes the diagnosis of the first case of community transmission of SARS-CoV-2 in the Republic of Ireland. Cases: Case 1: A 25 year old male presented with dyspnoea, cough and high fevers for 4 days. He was commenced on broad spectrum antimicrobials and oxygen therapy. His respiratory function deteriorated in spite of these measures and he required mechanical ventilation. CT showed left upper lobe consolidation as well as multifocal ground-glass opacification. Case 2: A 43 year-old male presented with headache and was found incidentally to have pneumonia. He was recently diagnosed with pituitary apoplexy secondary to an adenoma with resultant pituitary insufficiency but MRI brain was stable. His respiratory function deteriorated in spite of antibiotics and he required mechanical ventilation. CT showed likely atypical infection with resultant ARDS. Outcome: Both underwent nasopharyngeal RT-PCR testing for SARS-CoV-2. Patient 2 was positive. Patient 1 was extubated and made a good recovery. Patient 2 was transferred to another centre for ECMO therapy. He died 27 days after transfer. Conclusion: Given the atypical presentations in generally otherwise young and healthy individuals, the decision was made outside of national guidance to perform testing for SARS-CoV-2. This diagnosis had far-reaching implications for the SARSCoV-2 pandemic within Ireland.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidP78en
dc.identifier.citationFaller, E., Lapthorne, S., Barry, R., Shamile, F., Salleh, F., Doyle, D., O’Halloran, D., Prentice, M. and Sadlier, C. (2020) ‘The presentation and diagnosis of the first known community transmitted case of SARS-CoV-2 in the Republic of Ireland', Irish Medical Journal, 113(5), P78 (5pp). Available at: http://www.imj.ie/wp-content/uploads/2020/07/The-Presentation-Diagnosis-of-The-First-Known-Community-Transmitted-Case-of-SARS-CoV-2-in-the-Republic-of-Ireland.pdf (Accessed: 30 November 2020)en
dc.identifier.endpage5en
dc.identifier.issn0332-3102
dc.identifier.issued5en
dc.identifier.journaltitleIrish Medical Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10792
dc.identifier.volume113en
dc.language.isoenen
dc.publisherIrish Medical Organisationen
dc.relation.urihttp://www.imj.ie/wp-content/uploads/2020/07/The-Presentation-Diagnosis-of-The-First-Known-Community-Transmitted-Case-of-SARS-CoV-2-in-the-Republic-of-Ireland.pdf
dc.rights© 2020, Irish Medical Journal. All rights reserved.en
dc.subjectSARS-CoV-2en
dc.subjectCommunity transmissionen
dc.subjectRepublic of Irelanden
dc.titleThe presentation and diagnosis of the first known community transmitted case of SARS-CoV-2 in the Republic of Irelanden
dc.typeArticle (peer-reviewed)en
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