Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

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dc.contributor.authorOsmanov, Ismail M.
dc.contributor.authorSpiridonova, Ekaterina
dc.contributor.authorBobkova, Polina
dc.contributor.authorGamirova, Aysylu
dc.contributor.authorShikhaleva, Anastasia
dc.contributor.authorAndreeva, Margarita
dc.contributor.authorBlyuss, Oleg
dc.contributor.authorEl-Taravi, Yasmin
dc.contributor.authorDunnGalvin, Audrey
dc.contributor.authorComberiati, Pasquale
dc.contributor.authorPeroni, Diego G.
dc.contributor.authorApfelbacher, Christian
dc.contributor.authorGenuneit, Jon
dc.contributor.authorMazankova, Lyudmila
dc.contributor.authorMiroshina, Alexandra
dc.contributor.authorChistyakova, Evgeniya
dc.contributor.authorSamitova, Elmira
dc.contributor.authorBorzakova, Svetlana
dc.contributor.authorBondarenko, Elena
dc.contributor.authorKorsunskiy, Anatoliy A.
dc.contributor.authorKonova, Irina
dc.contributor.authorWulf Hanson, Sarah
dc.contributor.authorCarson, Gail
dc.contributor.authorSigfrid, Louise
dc.contributor.authorScott, Janet T.
dc.contributor.authorGreenhawt, Matthew
dc.contributor.authorWhittaker, Elizabeth A.
dc.contributor.authorGarralda, Elena
dc.contributor.authorSwann, Olivia V.
dc.contributor.authorBuonsenso, Danilo
dc.contributor.authorNicholls, Dasha E.
dc.contributor.authorSimpson, Frances
dc.contributor.authorJones, Christina
dc.contributor.authorSemple, Malcolm G.
dc.contributor.authorWarner, John O.
dc.contributor.authorVos, Theo
dc.contributor.authorOlliaro, Piero
dc.contributor.authorMunblit, Daniel
dc.date.accessioned2022-09-20T15:57:47Z
dc.date.available2022-09-20T15:57:47Z
dc.date.issued2022-02
dc.date.updated2022-09-20T15:45:15Z
dc.description.abstractBackground: The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors. Methods: This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved. Results: 518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3–15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (OR 2.74, 95% CI 1.37–5.75) and “12–18 years” (OR 2.68, 95% CI 1.41–5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04–2.67). Conclusions: A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid2101341en
dc.identifier.citationOsmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A.,Andreeva, M., Blyuss, O., El-Taravi, Y., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Mazankova, L., Miroshina, A., Chistyakova, E., Samitova, E., Borzakova, S., Bondarenko, E., Korsunskiy, A. A., Konova, I., Wulf Hanson, S., Carson, G., Sigfrid, L., Scott, J. T., Greenhawt, M., Whittaker, E. A., Garralda, E., Swann, O. V., Buonsenso, D., Nicholls, D. E., Simpson, F., Jones, C., Semple, M. G., Warner, J. O., Vos, T., Olliaro, P., Munblit, D. and the Sechenov StopCOVID Research Team (2022) 'Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study', European Respiratory Journal, 59(2), 2101341 (11pp). doi: 10.1183/13993003.01341-2021en
dc.identifier.doi10.1183/13993003.01341-2021en
dc.identifier.eissn1399-3003
dc.identifier.endpage11en
dc.identifier.issn0903-1936
dc.identifier.issued2en
dc.identifier.journaltitleEuropean Respiratory Journalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13623
dc.identifier.volume59en
dc.language.isoenen
dc.publisherEuropean Respiratory Societyen
dc.rights© 2022, the authors. This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPost-COVID-19 conditionen
dc.subjectPreviously hospitalised childrenen
dc.titleRisk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort studyen
dc.typeArticle (peer-reviewed)en
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