Efficient determination of non-steroidal anti-inflammatory drugs by micellar electrokinetic chromatography in wastewater

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dc.contributor.authorAlatawi, Hanan
dc.contributor.authorHogan, Anna
dc.contributor.authorAlbalawi, Ibtihaj
dc.contributor.authorAlsefri, Samia
dc.contributor.authorMoore, Eric
dc.contributor.funderMinistry of Higher Education of Saudi Arabiaen
dc.date.accessioned2023-02-23T15:03:57Z
dc.date.available2023-02-23T15:03:57Z
dc.date.issued2023-01
dc.date.updated2023-02-23T14:42:00Z
dc.description.abstractRecently, non-steroidal anti-inflammatory drugs (NSAIDs) have been increasingly used in humans and animals. Despite being effective against a wide variety of diseases, they pose a threat to aquatic environments. In the current work, a highly efficient, selective, and sensitive micellar electrokinetic chromatography (MEKC) method was developed for the determination of five NSAIDs in environmental water samples. The optimal separation BGE was 15 mM borate buffer (pH 9), 90 mM SDS, and 10% methanol at a separation voltage of 15 kV and a hydrodynamic injection of 10 mbar for 5 s. The results presented in this study provide a higher number of theoretical plates N > 780000 with excellent RSDs of 0.1–1.5% and great sensitivity (3–15 mgL−1) for NSAIDs. To validate this method, the solid phase extraction method was optimized using two different cartridges (C18 and Oasis HLB); the results showed excellent recoveries (73–111.6%) for all the analytes in wastewater samples.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlatawi, H., Hogan, A., Albalawi, I., Alsefri, S. and Moore, E. (2023) ‘Efficient determination of non-steroidal anti-inflammatory drugs by micellar electrokinetic chromatography in wastewater’, Analytical Methods, (8pp). doi: 10.1039/D2AY01807Aen
dc.identifier.doi10.1039/d2ay01807aen
dc.identifier.endpage8en
dc.identifier.issn1759-9679
dc.identifier.journaltitleAnalytical Methodsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14239
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.rights© The Royal Society of Chemistry 2023.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en
dc.subjectNon-steroidal anti-inflammatory drugsen
dc.subjectNSAIDsen
dc.subjectMicellar electrokinetic chromatographyen
dc.subjectMEKCen
dc.subjectWastewater samplesen
dc.titleEfficient determination of non-steroidal anti-inflammatory drugs by micellar electrokinetic chromatography in wastewateren
dc.typeArticle (peer-reviewed)en
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