Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients

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dc.contributor.authorO'Sullivan, Finbarr
dc.contributor.authorO'Sullivan, Janet N.
dc.contributor.authorHuang, Jian
dc.contributor.authorDoot, Robert
dc.contributor.authorMuzi, Mark
dc.contributor.authorSchubert, Erin
dc.contributor.authorPeterson, Lanell
dc.contributor.authorDunnwald, Lisa K.
dc.contributor.authorMankoff, David M.
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderNational Institutes of Health
dc.date.accessioned2018-07-18T11:56:19Z
dc.date.available2018-07-18T11:56:19Z
dc.date.issued2018
dc.description.abstractBlood flow-metabolism mismatch from dynamic positron emission tomography (PET) studies with O-15-labeled water (H2O) and F-18-labeled fluorodeoxyglucose (FDG) has been shown to be a promising diagnostic for locally advanced breast cancer (LABCa) patients. The mismatch measurement involves kinetic analysis with the arterial blood time course (AIF) as an input function. We evaluate the use of a statistical method for AIF extraction (SAIF) in these studies. Fifty three LABCa patients had dynamic PET studies with H2O and FDG. For each PET study, two AIFs were recovered, an SAIF extraction and also a manual extraction based on a region of interest placed over the left ventricle (LV-ROI). Blood flow-metabolism mismatch was obtained with each AIF, and kinetic and prognostic reliability comparisons were made. Strong correlations were found between kinetic assessments produced by both AIFs. SAIF AIFs retained the full prognostic value, for pathologic response and overall survival, of LV-ROI AIFs. (c) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en
dc.description.sponsorshipNational Institutes of Health (U01-CA148131, P50-CA138293, R50-CA211270, PO1-CA-42045)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid11010
dc.identifier.citationO’Sullivan, F., O'Sullivan, J. N., Huang, J., Doot, R., Muzi, M., Schubert, E., Peterson, L., Dunnwald, L. K. and Mankoff, D. M. (2017) 'Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients', Journal of Medical Imaging, 5(1), 011010 (9pp). doi: 10.1117/1.JMI.5.1.011010en
dc.identifier.doi10.1117/1.JMI.5.1.011010
dc.identifier.endpage9
dc.identifier.issn2329-4302
dc.identifier.issued1
dc.identifier.journaltitleJournal of Medical Imagingen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6473
dc.identifier.volume5
dc.language.isoenen
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/11/PI/1027/IE/Statistical Methods for Molecular Imaging of Cancer with PET/
dc.relation.urihttps://www.spiedigitallibrary.org/journals/journal-of-medical-imaging/volume-5/issue-01/011010/Assessment-of-a-statistical-AIF-extraction-method-for-dynamic-PET/10.1117/1.JMI.5.1.011010.full?SSO=1
dc.rights© 2017, the Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/?theme=Running_Club
dc.subjectAIF extractionen
dc.subjectBreast canceren
dc.subjectBlood flow-metabolism mismatchen
dc.subjectPhysiologically based pharmacokinetic modelen
dc.subjectKinetic analysisen
dc.subjectPositron emission tomographyen
dc.titleAssessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patientsen
dc.typeArticle (peer-reviewed)en
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