Expanding the human proteome with microproteins and peptideins

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dc.contributor.authorDeutsch, Eric W.
dc.contributor.authorKok, Leron W.
dc.contributor.authorMudge, Jonathan M.
dc.contributor.authorValls, Cristian F.
dc.contributor.authorJungreis, Irwin
dc.contributor.authorRuiz-Orera, Jorge
dc.contributor.authorSun, Zhi
dc.contributor.authorKusebauch, Ulrike
dc.contributor.authorFierro-Monti, Ivo
dc.contributor.authorAbelin, Jennifer G.
dc.contributor.authorAlba, M. Mar
dc.contributor.authorAspden, Julie L.
dc.contributor.authorBandyopadhyay, Sreejan
dc.contributor.authorBanerjee, Kaushik
dc.contributor.authorBaranov, Pavel V.
dc.contributor.authorBazzini, Ariel A.
dc.contributor.authorBourassa, Francis
dc.contributor.authorBruford, Elspeth A.
dc.contributor.authorCalviello, Lorenzo
dc.contributor.authorCarr, Steven A.
dc.contributor.authorCarvunis, Anne Ruxandra
dc.contributor.authorChothani, Sonia
dc.contributor.authorClauwaert, Jim
dc.contributor.authorDean, Kellie
dc.contributor.authorFaridi, Pouya
dc.contributor.authorFrankish, Adam
dc.contributor.authorGoodale, Amy
dc.contributor.authorGreen, Thomas
dc.contributor.authorHubner, Norbert
dc.contributor.authorIngolia, Nicholas T.
dc.contributor.authorKellis, Manolis
dc.contributor.authorMagrane, Michele
dc.contributor.authorMartin, Maria Jesus
dc.contributor.authorMartinez, Thomas F.
dc.contributor.authorMenschaert, Gerben
dc.contributor.authorOhler, Uwe
dc.contributor.authorOrchard, Sandra
dc.contributor.authorPotter, Alisa
dc.contributor.authorRackham, Owen J.L.
dc.contributor.authorRees, Matthew G.
dc.contributor.authorRoot, David E.
dc.contributor.authorRoth, Jennifer A.
dc.contributor.authorRoucou, Xavier
dc.contributor.authorSialana, Fernando J.
dc.contributor.authorSlavoff, Sarah A.
dc.contributor.authorŚwirski, Michał I.
dc.contributor.authorTierney, Jack A.S.
dc.contributor.authorTrifiro, Félix Antoine
dc.contributor.authorValen, Eivind
dc.contributor.authorVasylieva, Valeriia
dc.contributor.authorWacholder, Aaron
dc.contributor.authorWang, Shengbo
dc.contributor.authorWang, Li
dc.contributor.authorWeissman, Jonathan S.
dc.contributor.authorWu, Wei
dc.contributor.authorXie, Zhi
dc.contributor.authorChoudhary, Jyoti S.
dc.contributor.authorBassani-Sternberg, Michal
dc.contributor.authorVizcaíno, Juan Antonio
dc.contributor.authorTernette, Nicola
dc.contributor.authorBrunet, Marie A.
dc.contributor.authorMoritz, Robert L.
dc.contributor.authorPrensner, John R.
dc.contributor.authorvan Heesch, Sebastiaan
dc.contributor.funderUniversité de Sherbrooke, UDS
dc.contributor.funderDutch National Growth Fund
dc.contributor.funderTough2gether Foundation
dc.contributor.funderOffice of the Director
dc.contributor.funderBroad Institute, BI
dc.contributor.funderDMG Research Funding Alliance
dc.contributor.funderRogel Cancer Center, University of Michigan
dc.contributor.funderChad Carr Pediatric Brain Tumor Center
dc.contributor.funderFondation KickCancer
dc.contributor.funderDIPG
dc.contributor.funderNational Institute of General Medical Sciences, NIGMS
dc.contributor.funderVilla Joep
dc.contributor.funderDivision of Program Coordination, Planning, and Strategic Initiatives, DPCPSI
dc.contributor.funderCRIDO
dc.contributor.funderImagine for Margo
dc.contributor.funderFederazione Italiana Associazioni Genitori e Guariti Oncoematologia Pediatrica
dc.contributor.funderEU Horizon 2020 Pathfinder Program
dc.contributor.funderHyundai Hope on Wheels Foundation
dc.contributor.funderStichting Reggeborgh and Villa Joep
dc.contributor.funderFonds Cancers (FOCA, Belgium)
dc.contributor.funderHorizon 2020 Framework Programme
dc.contributor.funderOncode Institute
dc.contributor.funderCRIDO Roots of the Future scholarship and the Poland National Science Centre
dc.contributor.funderStichting Reggeborgh
dc.contributor.funderFight Kids Cancer Funding Programme
dc.contributor.funderCentro Singular de Investigación de Galicia, CINBIO
dc.contributor.funderNational Institute of Allergy and Infectious Diseases, NIAID
dc.contributor.funderYuvaan Tiwari Foundation
dc.contributor.funderVictorian Cancer Agency, VCA
dc.contributor.funderKWF Kankerbestrijding, KWF
dc.contributor.funderNational Heart, Lung, and Blood Institute, NHLBI
dc.contributor.funderFondatioun Kriibskrank Kanner
dc.contributor.funderMorgan Adams Foundation
dc.contributor.funderHope Foundation
dc.contributor.funderFonds Cancers
dc.contributor.funderNational Eye Institute, NEI
dc.contributor.funderStichting Kinderen Kankervrij
dc.contributor.funderFundacja na rzecz Nauki Polskiej, FNP
dc.contributor.funderCRIS Cancer Foundation
dc.contributor.funderCenter for Cancer Research, CCR
dc.contributor.funderDr. Miriam and Sheldon G. Adelson Medical Research Foundation, AMRF
dc.contributor.funderNational Institute on Aging, NIA
dc.contributor.funderBen and Catherine Ivy Foundation, BCIF
dc.contributor.funderRTI
dc.contributor.funderV Foundation for Cancer Research, VFCR, V2024-013
dc.contributor.funderNarodowe Centrum Nauki, NCN, UMO-2021/41/B/NZ2/03036
dc.contributor.funderNational Science Foundation, NSF, MRI-1920268-DBI-1933311
dc.contributor.funderAndrew McDonough B+ Foundation, AMBF, 1548557
dc.contributor.funderOncode Accelerator, NGFOP2201
dc.contributor.funderH2020 Marie Skłodowska-Curie Actions, MSCA, 945405
dc.contributor.funderNederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO, VI.Vidi.223.022
dc.contributor.funderDamon Runyon Cancer Research Foundation, DRCRF, CI-127-24
dc.contributor.funderNational Institute of Diabetes and Digestive and Kidney Diseases, NIAMDD, U24HG007822
dc.contributor.funderBiotechnology and Biological Sciences Research Council, AFRC, BB/S01781X/1-BB/Y513829/1
dc.contributor.funderLindonlight Collective, GR-24-008-GR-24-012
dc.contributor.funderSanté, FRQS, 354090-352705-367740
dc.contributor.funderCannonball Kids' cancer Foundation, CKc, 45
dc.contributor.funderNational Human Genome Research Institute, NHGRI, U24HG007234-U24HG00334
dc.contributor.funderLung Cancer Research Foundation, LCRF, 1491799
dc.contributor.funderNational Institutes of Health, USNIH, S10 OD026936-R35GM157126-P01CA206978-R01 GM087221-R24 GM148372
dc.contributor.funderDeutsche Forschungsgemeinschaft, DFG, CRC 1470-CRC 1700
dc.contributor.funderWellcome Trust, WT, 223745/Z/21/Z
dc.contributor.funderNational Cancer Institute, NCI, K08-CA263552-01A1-U24CA270823-U01CA271402
dc.contributor.funderNational Health and Medical Research Council, NHMRC, U24HG007234-222155/Z/20/Z
dc.contributor.funderNature et technologies, FRQNT, 354964
dc.contributor.funderResearch Ireland, 20/FFP-A/8929-R35GM157126-U01CA271402-P01CA206978-U24CA270823
dc.contributor.funderNatural Sciences and Engineering Research Council of Canada, CRSNG, RTI-2024-00556-RGPIN-2023-05203
dc.contributor.funderAmerican Brain Tumor Association, ABTA, DG2500077
dc.contributor.funderEngineering and Physical Sciences Research Council, SRC, EP/Y035984/1
dc.contributor.funderEuropean Molecular Biology Laboratory, EMBL, U24HG00334
dc.contributor.funderEuropean Research Council, ERC, AdG788970
dc.date.accessioned2026-06-30T13:50:08Z
dc.date.available2026-06-30T13:50:08Z
dc.date.issued2026-06-18
dc.description.abstractA major scientific drive is to characterize the protein-coding genome, which is a primary basis for studying human health. But the fundamental question remains of what has been missed in previous analyses. Over the past decade, the translation of non-canonical open reading frames (ncORFs) has been observed across human cell types and disease states1, 2–3, with major implications for biomedical science. However, a key gap in knowledge has been which ncORFs produce small microproteins or alternative protein molecules that contribute to the human proteome. Here we report the collaborative efforts of the TransCODE Consortium4 to produce a consensus landscape of protein-level evidence for ncORFs. We show that about 25% of a set of 7,264 ncORFs gives rise to detectable peptides in a large-scale analysis of 95,520 proteomics experiments. We develop an annotation framework for ncORF-encoded microproteins as human proteins and codify the new conceptual model of ‘peptideins’ as microproteins that have indeterminate potential as functional proteins. To probe the biological implications of peptideins, we create an evolutionary analysis approach, termed ORF relative branch length (ORBL), and determine that evolutionary constraint is common and associates with observation of ncORF-derived peptides. We then characterize a pan-essential cellular phenotype for one peptidein from the OLMALINC long non-coding RNA. Overall, we generate public research tools supported by GENCODE and PeptideAtlas and advance biomedical discovery for understudied components of the human proteome.en
dc.description.sponsorshipWe acknowledge the authors of many excellent research publications in this field. This work was funded in part by the National Institutes of Health grants R01 GM087221 (E.W.D., R.L.M.), R24 GM148372 (E.W.D.), S10 OD026936 (R.L.M.) and by the National Science Foundation grants DBI-1933311 (E.W.D.) and MRI-1920268 (R.L.M.). J.R.P. acknowledges funding from the National Institutes of Health/National Cancer Institute (K08-CA263552-01A1)
dc.description.sponsorshipthe V Foundation for Cancer Research (V2024-013)
dc.description.sponsorshipTough2gether Foundation
dc.description.sponsorshipHyundai Hope on Wheels Foundation
dc.description.sponsorshipthe Yuvaan Tiwari Foundation
dc.description.sponsorshipDIPG/DMG Research Funding Alliance
dc.description.sponsorshipBook for Hope Foundation
dc.description.sponsorshipCureSearch for Cancer Research
dc.description.sponsorshipMorgan Adams Foundation
dc.description.sponsorshipand the Andrew McDonough B+ Foundation (1548557)
dc.description.sponsorshipthe Lindonlight Collective (GR-24-008 and GR-24-012)
dc.description.sponsorshipthe Lung Cancer Research Foundation (1491799)
dc.description.sponsorshipthe American Brain Tumor Association (DG2500077)
dc.description.sponsorshipthe Cannonball Kids Cancer Foundation (45)
dc.description.sponsorshipthe Chad Carr Pediatric Brain Tumor Center
dc.description.sponsorshipand the University of Michigan Rogel Cancer Center. J.R.P. is the Ben and Catherine Ivy Foundation Clinical Investigator of the Damon Runyon Cancer Research Foundation (CI-127-24). S.v.H. acknowledges funding from Fonds Cancers (FOCA, Belgium), Stichting Reggeborgh and Villa Joep. This project was partially supported by the Fight Kids Cancer Funding Programme, supported by Imagine for Margo, Fondation KickCancer, Fondatioun Kriibskrank Kanner, Federazione Italiana Associazioni Genitori e Guariti Oncoematologia Pediatrica, Cris Cancer Foundation and Stichting Kinderen Kankervrij (KiKa). This publication is part of the project “Evolutionarily young microproteins in childhood brain cancer” with project number VI.Vidi.223.022 of the research programme NWO talent programme Vidi, which is partly financed by the Dutch Research Council (NWO), awarded to S.v.H. Research reported in this publication was supported by Oncode Accelerator, a Dutch National Growth Fund project under grant number NGFOP2201, awarded to S.v.H. This work is co-financed by Oncode Institute, which is partly funded by the Dutch Cancer Society. J.A.V. acknowledges funding from the Wellcome Trust (223745/Z/21/Z), BBSRC (BB/Y513829/1, BB/S01781X/1) and EPSRC (EP/Y035984/1). M.M., M.J.M. and S.O. acknowledge funding from the National Human Genome Research Institute (NHGRI), Office of Director (OD/DPCPSI/ODSS), National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Aging (NIA), National Institute of General Medical Sciences (NIGMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Eye Institute (NEI), National Cancer Institute (NCI), National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health under Award Number U24HG007822. I.F.-M. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 945405. P.V.B. acknowledges funding from Taighde Éireann—Research Ireland (20/FFP-A/8929). T.F.M. acknowledges financial support from NIH grant R35GM157126. J.G.A and S.A.C. are supported in part by grants P01CA206978 from the NIH, and grants U24CA270823 and U01CA271402 from the NCI Clinical Proteomic Tumor Analysis Consortium program, as well as a grant from the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation to S.A.C. J.G.A. acknowledges funding from the Broad Institute’s Merkin Institute Fellowship. N.H. was supported by ERC Advanced Grant (EU Horizon 2020, AdG788970), Deutsche Forschungsgemeinschaft (DFG
dc.description.sponsorshipCRC 1470 and CRC 1700) and the EU Horizon 2020 Pathfinder Program. P.F. was supported by a Victorian Cancer Agency Mid-Career Fellowship and the National Health and Medical Research Council of Australia (NHMRC). J.M.M., A.F., J.R.P., and I.J. are supported by the National Human Genome Research Institute (NHGRI) of the US National Institutes of Health (NIH) under award number U24HG007234. J.M.M. and A.F. are supported by the Wellcome Trust (grant number 222155/Z/20/Z). J.M.M., A.F., J.A.S.T., J.A.V., M.M., M.J.M. and S.O are supported by EMBL core funding. E.A.B. is funded by the NHGRI grant U24HG00334. M.A.B. acknowledges funding from the NSERC (Discovery grant RGPIN-2023-05203 and RTI grant RTI-2024-00556). M.A.B. is supported by a FRQS Junior 2 award (367740) and a research chair from the Centre de Recherche Medicale de l’Universite de Sherbrooke (CRMUS). F.-A.T. and F.B. are supported by FRQS scholarships (354090 and 352705, respectively). V.V. is supported by a FRQNT scholarship (354964). J.S.C. and S.B. acknowledge funding from the Wellcome Trust (223745/Z/21/Z) and Biomedical Research Centre. M.I.Ś. was supported by Foundation for Polish Science START scholarship, CRIDO Roots of the Future scholarship and the Poland National Science Centre (UMO-2021/41/B/NZ2/03036). We thank J. Causon, K. Tran and C. Feasley for providing access and for data collection on the Sciex ZenoTOF 8600 MS system. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Ensembl is a registered trademark of EMBL. We acknowledge the authors of many excellent research publications in this field. This work was funded in part by the National Institutes of Health grants R01 GM087221 (E.W.D., R.L.M.), R24 GM148372 (E.W.D.), S10 OD026936 (R.L.M.) and by the National Science Foundation grants DBI-1933311 (E.W.D.) and MRI-1920268 (R.L.M.). J.R.P. acknowledges funding from the National Institutes of Health/National Cancer Institute (K08-CA263552-01A1)
dc.description.sponsorshipthe V Foundation for Cancer Research (V2024-013)
dc.description.sponsorshipTough2gether Foundation
dc.description.sponsorshipHyundai Hope on Wheels Foundation
dc.description.sponsorshipthe Yuvaan Tiwari Foundation
dc.description.sponsorshipDIPG/DMG Research Funding Alliance
dc.description.sponsorshipBook for Hope Foundation
dc.description.sponsorshipCureSearch for Cancer Research
dc.description.sponsorshipMorgan Adams Foundation
dc.description.sponsorshipand the Andrew McDonough B+ Foundation (1548557)
dc.description.sponsorshipthe Lindonlight Collective (GR-24-008 and GR-24-012)
dc.description.sponsorshipthe Lung Cancer Research Foundation (1491799)
dc.description.sponsorshipthe American Brain Tumor Association (DG2500077)
dc.description.sponsorshipthe Cannonball Kids Cancer Foundation (45)
dc.description.sponsorshipthe Chad Carr Pediatric Brain Tumor Center
dc.description.sponsorshipand the University of Michigan Rogel Cancer Center. J.R.P. is the Ben and Catherine Ivy Foundation Clinical Investigator of the Damon Runyon Cancer Research Foundation (CI-127-24). S.v.H. acknowledges funding from Fonds Cancers (FOCA, Belgium), Stichting Reggeborgh and Villa Joep. This project was partially supported by the Fight Kids Cancer Funding Programme, supported by Imagine for Margo, Fondation KickCancer, Fondatioun Kriibskrank Kanner, Federazione Italiana Associazioni Genitori e Guariti Oncoematologia Pediatrica, Cris Cancer Foundation and Stichting Kinderen Kankervrij (KiKa). This publication is part of the project “Evolutionarily young microproteins in childhood brain cancer” with project number VI.Vidi.223.022 of the research programme NWO talent programme Vidi, which is partly financed by the Dutch Research Council (NWO), awarded to S.v.H. Research reported in this publication was supported by Oncode Accelerator, a Dutch National Growth Fund project under grant number NGFOP2201, awarded to S.v.H. This work is co-financed by Oncode Institute, which is partly funded by the Dutch Cancer Society. J.A.V. acknowledges funding from the Wellcome Trust (223745/Z/21/Z), BBSRC (BB/Y513829/1, BB/S01781X/1) and EPSRC (EP/Y035984/1). M.M., M.J.M. and S.O. acknowledge funding from the National Human Genome Research Institute (NHGRI), Office of Director (OD/DPCPSI/ODSS), National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Aging (NIA), National Institute of General Medical Sciences (NIGMS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Eye Institute (NEI), National Cancer Institute (NCI), National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health under Award Number U24HG007822. I.F.-M. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 945405. P.V.B. acknowledges funding from Taighde Éireann—Research Ireland (20/FFP-A/8929). T.F.M. acknowledges financial support from NIH grant R35GM157126. J.G.A and S.A.C. are supported in part by grants P01CA206978 from the NIH, and grants U24CA270823 and U01CA271402 from the NCI Clinical Proteomic Tumor Analysis Consortium program, as well as a grant from the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation to S.A.C. J.G.A. acknowledges funding from the Broad Institute’s Merkin Institute Fellowship. N.H. was supported by ERC Advanced Grant (EU Horizon 2020, AdG788970), Deutsche Forschungsgemeinschaft (DFG
dc.description.sponsorshipCRC 1470 and CRC 1700) and the EU Horizon 2020 Pathfinder Program. P.F. was supported by a Victorian Cancer Agency Mid-Career Fellowship and the National Health and Medical Research Council of Australia (NHMRC). J.M.M., A.F., J.R.P., and I.J. are supported by the National Human Genome Research Institute (NHGRI) of the US National Institutes of Health (NIH) under award number U24HG007234. J.M.M. and A.F. are supported by the Wellcome Trust (grant number 222155/Z/20/Z). J.M.M., A.F., J.A.S.T., J.A.V., M.M., M.J.M. and S.O are supported by EMBL core funding. E.A.B. is funded by the NHGRI grant U24HG00334. M.A.B. acknowledges funding from the NSERC (Discovery grant RGPIN-2023-05203 and RTI grant RTI-2024-00556). M.A.B. is supported by a FRQS Junior 2 award (367740) and a research chair from the Centre de Recherche Medicale de l’Universite de Sherbrooke (CRMUS). F.-A.T. and F.B. are supported by FRQS scholarships (354090 and 352705, respectively). V.V. is supported by a FRQNT scholarship (354964). J.S.C. and S.B. acknowledge funding from the Wellcome Trust (223745/Z/21/Z) and Biomedical Research Centre. M.I.Ś. was supported by Foundation for Polish Science START scholarship, CRIDO Roots of the Future scholarship and the Poland National Science Centre (UMO-2021/41/B/NZ2/03036). We thank J. Causon, K. Tran and C. Feasley for providing access and for data collection on the Sciex ZenoTOF 8600 MS system. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Ensembl is a registered trademark of EMBL.
dc.description.versionPublished Version
dc.format.extent13
dc.format.mimetypeapplication/pdfen
dc.identifier.authororcidDeutsch, Eric W.
dc.identifier.authororcidKok, Leron W.
dc.identifier.authororcidMudge, Jonathan M.
dc.identifier.authororcidValls, Cristian F.
dc.identifier.authororcidJungreis, Irwin
dc.identifier.authororcidRuiz-Orera, Jorge
dc.identifier.authororcidSun, Zhi
dc.identifier.authororcidKusebauch, Ulrike
dc.identifier.authororcidFierro-Monti, Ivo
dc.identifier.authororcidAbelin, Jennifer G.
dc.identifier.authororcidAlba, M. Mar
dc.identifier.authororcidAspden, Julie L.
dc.identifier.authororcidBandyopadhyay, Sreejan
dc.identifier.authororcidBanerjee, Kaushik
dc.identifier.authororcidBaranov, Pavel V.
dc.identifier.authororcidBazzini, Ariel A.
dc.identifier.authororcidBourassa, Francis
dc.identifier.authororcidBruford, Elspeth A.
dc.identifier.authororcidCalviello, Lorenzo
dc.identifier.authororcidCarr, Steven A.
dc.identifier.authororcidCarvunis, Anne Ruxandra
dc.identifier.authororcidChothani, Sonia
dc.identifier.authororcidClauwaert, Jim
dc.identifier.authororcidDean, Kellie§0000-0002-3213-8181
dc.identifier.authororcidFaridi, Pouya
dc.identifier.authororcidFrankish, Adam
dc.identifier.authororcidGoodale, Amy
dc.identifier.authororcidGreen, Thomas
dc.identifier.authororcidHubner, Norbert
dc.identifier.authororcidIngolia, Nicholas T.
dc.identifier.authororcidKellis, Manolis
dc.identifier.authororcidMagrane, Michele
dc.identifier.authororcidMartin, Maria Jesus
dc.identifier.authororcidMartinez, Thomas F.
dc.identifier.authororcidMenschaert, Gerben
dc.identifier.authororcidOhler, Uwe
dc.identifier.authororcidOrchard, Sandra
dc.identifier.authororcidPotter, Alisa
dc.identifier.authororcidRackham, Owen J.L.
dc.identifier.authororcidRees, Matthew G.
dc.identifier.authororcidRoot, David E.
dc.identifier.authororcidRoth, Jennifer A.
dc.identifier.authororcidRoucou, Xavier
dc.identifier.authororcidSialana, Fernando J.
dc.identifier.authororcidSlavoff, Sarah A.
dc.identifier.authororcidŚwirski, Michał I.
dc.identifier.authororcidTierney, Jack A.S.
dc.identifier.authororcidTrifiro, Félix Antoine
dc.identifier.authororcidValen, Eivind
dc.identifier.authororcidVasylieva, Valeriia
dc.identifier.authororcidWacholder, Aaron
dc.identifier.authororcidWang, Shengbo
dc.identifier.authororcidWang, Li
dc.identifier.authororcidWeissman, Jonathan S.
dc.identifier.authororcidWu, Wei
dc.identifier.authororcidXie, Zhi
dc.identifier.authororcidChoudhary, Jyoti S.
dc.identifier.authororcidBassani-Sternberg, Michal
dc.identifier.authororcidVizcaíno, Juan Antonio
dc.identifier.authororcidTernette, Nicola
dc.identifier.authororcidBrunet, Marie A.
dc.identifier.authororcidMoritz, Robert L.
dc.identifier.authororcidPrensner, John R.
dc.identifier.authororcidvan Heesch, Sebastiaan
dc.identifier.citationDeutsch, E W, Kok, L W, Mudge, J M, Valls, C F, Jungreis, I, Ruiz-Orera, J, Sun, Z, Kusebauch, U, Fierro-Monti, I, Abelin, J G, Alba, M M, Aspden, J L, Bandyopadhyay, S, Banerjee, K, Baranov, P V, Bazzini, A A, Bourassa, F, Bruford, E A, Calviello, L, Carr, S A, Carvunis, A R, Chothani, S, Clauwaert, J, Dean, K, Faridi, P, Frankish, A, Goodale, A, Green, T, Hubner, N, Ingolia, N T, Kellis, M, Magrane, M, Martin, M J, Martinez, T F, Menschaert, G, Ohler, U, Orchard, S, Potter, A, Rackham, O J L, Rees, M G, Root, D E, Roth, J A, Roucou, X, Sialana, F J, Slavoff, S A, Świrski, M I, Tierney, J A S, Trifiro, F A, Valen, E, Vasylieva, V, Wacholder, A, Wang, S, Wang, L, Weissman, J S, Wu, W, Xie, Z, Choudhary, J S, Bassani-Sternberg, M, Vizcaíno, J A, Ternette, N, Brunet, M A, Moritz, R L, Prensner, J R & van Heesch, S 2026, 'Expanding the human proteome with microproteins and peptideins', Nature, vol. 654, no. 8119, pp. 813-825. https://doi.org/10.1038/s41586-026-10459-x
dc.identifier.doi10.1038/s41586-026-10459-x
dc.identifier.endpage825
dc.identifier.issn0028-0836
dc.identifier.issued8119
dc.identifier.journaltitleNature
dc.identifier.otherORCID: /0000-0002-3213-8181/work/231477570
dc.identifier.startpage813
dc.identifier.urihttps://hdl.handle.net/10468/18982
dc.identifier.volume654
dc.language.isoen
dc.publisherNature Research
dc.relation.urihttps://www.scopus.com/pages/publications/105038148448
dc.rights© The Author(s) 2026. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.statusPeer reviewed
dc.subjectHuman proteome
dc.subject[BiochemistryCellBiology]
dc.subjectMicroproteins
dc.subjectPeptideins
dc.titleExpanding the human proteome with microproteins and peptideinsen
dc.typeArticle (peer-reviewed)
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