Application of mathematical modelling to reducing and minimising energy requirement for oxygen transfer in batch stirred tank bioreactors

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dc.contributor.authorFitzpatrick, John J.
dc.contributor.authorGloanec, Franck
dc.contributor.authorMichel, Elisa
dc.contributor.authorBlondy, Johanna
dc.contributor.authorLauzeral, Anais
dc.date.accessioned2019-11-20T06:03:33Z
dc.date.available2019-11-20T06:03:33Z
dc.date.issued2019-02-03
dc.description.abstractIn this study, microbial kinetic and oxygen transfer modelling coupled with energy analysis was applied to investigate how manipulation and control of agitator power input and air flowrate can reduce and minimise the total energy requirement in a batch aerobic bioprocess subject to constraints. The study showed that major energy savings can be made by appropriate selection of these variables and how they are controlled throughout a bioprocess. In many bioprocesses, the oxygen concentration in the liquid is controlled at a constant value. This may be achieved by maintaining the agitator power at a constant value and varying the air flowrate or vice versa, or by continuously varying both. The modelling showed that the minimum or near-minimum total energy requirement occurred when operating at the onset of impeller flooding throughout the bioprocess by continuously varying both impeller power and air flowrate over the bioprocess time. Operating at the onset of flooding may not be practical to implement in practice. However, the minimum energy can be approached by dividing the bioprocess time into a small number of time segments with appropriately chosen constant agitator powers and varying the air flowrate within each segment. This is much more practical to implement.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid14en
dc.identifier.citationFitzpatrick, J.J., Gloanec, F., Michel, E., Blondy, J. and Lauzeral, A., 2019. Application of Mathematical Modelling to Reducing and Minimising Energy Requirement for Oxygen Transfer in Batch Stirred Tank Bioreactors. ChemEngineering, 3(1), (14). DOI:10.3390/chemengineering3010014en
dc.identifier.doi10.3390/chemengineering3010014en
dc.identifier.eissn2305-7084
dc.identifier.endpage21en
dc.identifier.issued1en
dc.identifier.journaltitleChemengineeringen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9151
dc.identifier.volume3en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttps://www.mdpi.com/2305-7084/3/1/14
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectEnergy efficiencyen
dc.subjectAerobic bioprocessen
dc.subjectBatch stirred tank bioreactoren
dc.subjectMathematical modellingen
dc.titleApplication of mathematical modelling to reducing and minimising energy requirement for oxygen transfer in batch stirred tank bioreactorsen
dc.typeArticle (peer-reviewed)en
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