Dietary bioactives and cardiovascular health

Simple item page
dc.check.embargoformatBoth hard copy thesis and e-thesisen
dc.check.opt-outYesen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.contributor.advisorKiely, Maireaden
dc.contributor.advisorLucey, Aliceen
dc.contributor.authorHeneghan, Clara
dc.contributor.funderDepartment of Agriculture and Rural Developmenten
dc.contributor.funderSeventh Framework Programmeen
dc.date.accessioned2018-02-14T13:36:32Z
dc.date.issued2017
dc.date.submitted2017
dc.description.abstractThe primary objective of this thesis was to investigate the efficacy of dietary bioactive compounds on cardiovascular disease (CVD) risk markers in adults with mildly elevated blood pressure (BP) through the implementation of two human dietary intervention studies: the Cardio-Rubus (blackberry-polyphenols) and Cardio-Protein (ovalbumin-derived peptides) randomised controlled trials (RCTs). Our findings indicate that the consumption of ovalbumin-derived peptides for 6-weeks does not have an effect on BP, blood lipids or glycaemic profile in adults [Cardio-Protein RCT]; similarly, supplementation with a polyphenol-rich blackberry beverage for 6 weeks does not appear to lower BP or improve blood lipids or glucose homeostasis in adults [Cardio-Rubus RCT]. In this RCT, considerable heterogeneity in participant responses to the polyphenol-rich beverage were observed. Inter-individual variation in participant response to polyphenol-based interventions has become a major challenge for the establishment of causal relationships between polyphenols and health outcomes. This was further reinforced in the findings of a systematic review evaluating evidence from berry-based RCTs on markers of cardio-metabolic health, which was conducted as part of this thesis. Of a total of 23 RCTs; 17 were ranked to be of high quality, of these 12 RCTs reported a beneficial effect on CVD risk, supporting consumption of berries as part of a cardio-protective diet. This thesis includes the first study to estimate dietary intakes of polyphenols in Irish adults, teens and children using nationally representative data. Beverages were the predominant contributor; providing a feasible method by which to increase polyphenol intakes. A modelling assessment demonstrated that hypothetically a polyphenol-rich beverage could meaningfully increase polyphenol intakes in the Irish population. Findings from this thesis inform and aim to address current challenges which face dietary interventions with bioactive compounds for the advancement of polyphenol research and the establishment of a causal link between polyphenols or peptides and cardio-metabolic health outcomes.en
dc.description.sponsorshipDepartment of Agriculture and Rural Development (FIRM Grant 13F539)en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHeneghan, C. 2017. Dietary bioactives and cardiovascular health. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/5462
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312090/EU/Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans/BACCHUSen
dc.rights© 2017, Clara Heneghan.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectPolyphenolsen
dc.subjectBioactivesen
dc.subjectBlackberryen
dc.subjectPeptide hydrolysatesen
dc.subjectDiet and cardiovascular diseaseen
dc.thesis.opt-outtrue
dc.titleDietary bioactives and cardiovascular healthen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoral Degree (Structured)en
dc.type.qualificationnamePhD (Food Science and Technology)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Abstract-updated.docx
Size:
15.8 KB
Format:
Microsoft Word XML
Description:
Abstract
License bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
license.txt
Size:
5.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Thumbnail Image
Name:
Clara Heneghan.pdf
Size:
32.4 KB
Format:
Adobe Portable Document Format
Description:
Opt-Out Form
Collections
Doctoral Theses
College of Science, Engineering and Food Science - Doctoral Theses
Food and Nutritional Sciences - Doctoral Theses