Biomimetic gold nanocomplexes for gene knockdown - will gold deliver dividends for siRNA nanomedicines?

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dc.contributor.authorGuo, Jianfeng
dc.contributor.authorRahme, Kamil
dc.contributor.authorFitzgerald, Kathleen A.
dc.contributor.authorHolmes, Justin D.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.funderIrish Research Councilen
dc.contributor.funderIrish Cancer Societyen
dc.date.accessioned2018-08-03T11:33:35Z
dc.date.available2018-08-03T11:33:35Z
dc.date.issued2015-08-27
dc.date.updated2018-08-02T18:42:58Z
dc.description.abstractRNA interference (RNAi) effectors such as small interfering RNA (siRNA) and micro RNA (miRNA) can selectively downregulate any gene implicated in the pathology of a disease. Therefore, RNAi-based therapies have immense potential for the treatment of a wide range of diseases. However, pharmacokinetic and pharmacodynamic studies have revealed that these therapeutic agents have poor bioactivity due to a number of factors, including insufficient plasma drug levels, short plasma half-lives, renal clearance, and hepatic metabolism. Non-viral delivery may facilitate the clinical application of siRNA-based therapeutics by helping to overcome these barriers. Recently, the potential of gold nanoparticles (AuNPs) as multifunctional carriers for transporting drugs, proteins, and genetic materials has been demonstrated. In this review, some of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chemistry have been described. In addition, the ability of AuNP-based formulation strategies to successfully overcome delivery barriers associated with siRNA, and the potential for this material to translate into safe and effective nanomedicines are critically discussed.en
dc.description.sponsorshipIrish Research Council (Postdoctoral Fellowship (No. GOIPD/2013/150); Irish Cancer Society (project grant (No. PCI11ODR))en
dc.description.statusPeer revieweden
dc.description.versionSubmitted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGuo, J., Rahme, K., Fitzgerald, K. A., Holmes, J. D. and O’Driscoll, C. M. (2015) 'Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines?', Nano Research, 8(10), pp. 3111-3140. doi: 10.1007/s12274-015-0829-4en
dc.identifier.doi10.1007/s12274-015-0829-4
dc.identifier.endpage3140en
dc.identifier.issn1998-0124
dc.identifier.issn1998-0000
dc.identifier.issued10en
dc.identifier.journaltitleNano Researchen
dc.identifier.startpage3111en
dc.identifier.urihttps://hdl.handle.net/10468/6575
dc.identifier.volume8en
dc.language.isoenen
dc.publisherSpringer Verlag; Tsinghua University Pressen
dc.relation.urihttp://www.springer.com/materials/nanotechnology/journal/12274
dc.rights© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2015. This is a pre-print of an article published in published in Nano Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12274-015-0829-4en
dc.subjectsiRNA deliveryen
dc.subjectRNA interference (RNAi)- based therapeuticsen
dc.subjectMultifunctional nanoparticlesen
dc.subjectNanotoxicity of gold nanoparticlesen
dc.titleBiomimetic gold nanocomplexes for gene knockdown - will gold deliver dividends for siRNA nanomedicines?en
dc.typeArticle (peer-reviewed)en
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