Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic

Simple item page
dc.contributor.authorVandenplas, Yvan
dc.contributor.authorLudwig, Thomas
dc.contributor.authorBouritius, Hetty
dc.contributor.authorAlliet, Philippe
dc.contributor.authorForde, Derek
dc.contributor.authorPeeters, Stefaan
dc.contributor.authorHuet, Frederic
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.funderNutricia Research Foundationen
dc.date.accessioned2018-02-01T11:30:43Z
dc.date.available2018-02-01T11:30:43Z
dc.date.issued2017-04-19
dc.description.abstractAim: We examined the effects on gastrointestinal (GI) tolerance of a novel infant formula that combined specific fermented formula (FERM) with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS), with a 9:1 ratio and concentration of 0.8 g/100 mL. Methods: This prospective, double-blind, randomised, controlled trial comprised 432 healthy, term infants aged 0–28 days whose parents decided to not start, or discontinued, breastfeeding. Infant formula with scGOS/lcFOS+50%FERM, scGOS/lcFOS+15%FERM, 50%FERM and scGOS/lcFOS were tested. Parents completed standardised seven-day diaries on GI symptoms, crying, sleeping and stool characteristics each month until the infants were 17 weeks. Results: All the formulas were well tolerated. At four weeks, the overall incidence of infantile colic was significantly lower (8%) with scGOS/lcFOS+50%FERM than scGOS/lcFOS (20%, p = 0.034) or 50%FERM (20%, p = 0.036). Longitudinal modelling showed that scGOS/lcFOS+50%FERM-fed infants also displayed a persistently lower daily crying duration and showed a consistent stool-softening effect than infants who received formula without scGOS/lcFOS. Conclusion: The combination of fermented formula with scGOS/lcFOS was well tolerated and showed a lower overall crying time, a lower incidence of infantile colic and a stool-softening effect in healthy term infants. These findings suggest for the first time that a specific infant formula has a preventive effect on infantile colic in formula-fed infants.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVandenplas, Y., Ludwig, T., Bouritius, H., Alliet, P., Forde, D., Peeters, S., Huet, F. and Hourihane, J. (2017) 'Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic', Acta Paediatrica, 106(7), pp. 1150-1158. doi:10.1111/apa.13844en
dc.identifier.doi10.1111/apa.13844
dc.identifier.endpage1158en
dc.identifier.issn1651-2227
dc.identifier.issued7en
dc.identifier.journaltitleActa Paediatricaen
dc.identifier.startpage1150en
dc.identifier.urihttps://hdl.handle.net/10468/5363
dc.identifier.volume106en
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and repro duction in any medium, provided the original work is properly cited and is not used for commercial purposesen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectFermented formulaen
dc.subjectGastrointestinal toleranceen
dc.subjectInfant formulaen
dc.subjectInfantile colicen
dc.subjectPrebioticen
dc.titleRandomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colicen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2767_PV.pdf
Size:
408.05 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Paediatrics and Child Health - Journal Articles