A cardiovascular occlusion method based on the use of a smart hydrogel

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dc.contributor.authorJackson, Nathan
dc.contributor.authorVerbrugghe, Peter
dc.contributor.authorCuypers, D.
dc.contributor.authorAdesanya, K.
dc.contributor.authorEngel, L.
dc.contributor.authorGlazer, P.
dc.contributor.authorDubruel, Peter
dc.contributor.authorMendes, Eduardo
dc.contributor.authorHerijigers, P.
dc.contributor.authorStam, Frank
dc.date.accessioned2016-06-10T08:51:09Z
dc.date.available2016-06-10T08:51:09Z
dc.date.issued2014-09-04
dc.date.updated2015-01-20T12:14:30Z
dc.description.abstractSmart hydrogels for biomedical applications are highly researched materials. However, integrating them into a device for implantation is difficult. This paper investigates an integrated delivery device designed to deliver an electro-responsive hydrogel to a target location inside a blood vessel with the purpose of creating an occlusion. The paper describes the synthesis and characterization of a Pluronic/methacrylic acid sodium salt electro-responsive hydrogel. Application of an electrical bias decelerates the expansion of the hydrogel. An integrated delivery system was manufactured to deliver the hydrogel to the target location in the body. Ex vivo and in vivo experiments in the carotid artery of sheep were used to validate the concept. The hydrogel was able to completely occlude the blood vessel reducing the blood flow from 245 to 0 ml/min after implantation. Ex vivo experiments showed that the hydrogel was able to withstand physiological blood pressures of > 270 mm·Hg without dislodgement. The results showed that the electro-responsive hydrogel used in this paper can be used to create a long-term occlusion in a blood vessel without any apparent side effects. The delivery system developed is a promising device for the delivery of electro-responsive hydrogels.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJackson, N., Verbrugghe, P., Cuypers, D., Adesanya, K., Engel, L., Glazer, P., Dubruel, P., Mendes, E., Herijigers, P. and Stam, F. (2014) 'A cardiovascular occlusion method based on the use of smart hydrogels', IEEE Transactions On Biomedical Engineering, 62(2), pp. 399-406. doi: 10.1109/TBME.2014.2353933en
dc.identifier.doi10.1109/TBME.2014.2353933
dc.identifier.endpage406en
dc.identifier.issn0018-9294
dc.identifier.issued2en
dc.identifier.journaltitleIEEE Transactions on Biomedical Engineeringen
dc.identifier.startpage399en
dc.identifier.urihttps://hdl.handle.net/10468/2715
dc.identifier.volume62en
dc.language.isoenen
dc.publisherIEEEen
dc.rights© 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en
dc.subjectBlood vesselen
dc.subjectCardiovascularen
dc.subjectDelivery deviceen
dc.subjectElectroactivationen
dc.subjectHydrogelen
dc.subjectOcclusionen
dc.titleA cardiovascular occlusion method based on the use of a smart hydrogelen
dc.typeArticle (peer-reviewed)en
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