Hypertensive disorders in pregnancy and cognitive outcomes in childhood and adolescence

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dc.contributor.authorDas, T.en
dc.contributor.authorKhashan, Asen
dc.contributor.authorHanrahan, M.en
dc.contributor.editorMehta, Shobhaen
dc.contributor.editorCronin, Pádraigen
dc.date.accessioned2025-10-28T13:55:02Z
dc.date.available2025-10-28T13:55:02Z
dc.date.issued2025en
dc.description.abstractBackground: Hypertensive disorders in pregnancy (HDP), including preeclampsia, have been linked to lower cognitive scores in offspring, but findings remain inconsistent. This study examines the relationship between maternal HDP and cognitive development in offspring aged 3–17 years. Methods: We conducted a cohort study using data from the UK Millennium Cohort Study (2001). Maternal HDP was examined as an exposure factor in relation to children’s cognitive abilities, including verbal and visuospatial outcomes. Cognitive delay was defined as scoring >1 SD below the mean and classified as “never delayed,” “delayed only once,” “persistent delay,” “early childhood delay,” or “adolescent onset delay.” Results: Among 5,994 singleton pregnancies, 460 were affected by maternal HDP. Mothers were primarily aged 30–39 years (51.6%) and predominantly Caucasian (86.2%). Adjusted odds ratios (OR) controlled for maternal characteristics (age, ethnicity, BMI, alcohol use, smoking, education, income) and offspring gender. No significant association was found between maternal HDP and verbal delay at 3 years (OR: 1.008, 95% CI: 0.783–1.297), 5 years (OR: 0.864, 95% CI: 0.659–1.133), or 7 years (OR: 1.034, 95% CI: 0.800–1.336). Similarly, visuospatial delay at 7 years (OR: 0.863, 95% CI: 0.679–1.097) and adolescence (14 years: OR: 0.871, 95% CI: 0.688–1.101; 17 years: OR: 1.069, 95% CI: 0.856–1.336) showed no significant association. Conclusion: Maternal HDP does not appear to significantly impact offspring cognitive development. Further research with larger cohorts is needed.en
dc.description.statusNot peer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDas, T., Khashan, A. and Hanrahan, M. (2025) 'Hypertensive disorders in pregnancy and cognitive outcomes in childhood and adolescence', UCC Student Medical Journal, 5, p.100. https://doi.org/10.33178/SMJ.2025.1.26en
dc.identifier.doi10.33178/SMJ.2025.1.26en
dc.identifier.endpage100en
dc.identifier.issn2737-7237
dc.identifier.journalabbrevUCC SMJ
dc.identifier.journaltitleUCC Student Medical Journalen
dc.identifier.startpage100en
dc.identifier.urihttps://hdl.handle.net/10468/18103
dc.identifier.volume5
dc.language.isoenen
dc.publisherUCC Medical Research and Technology Societyen
dc.rights© 2025, the Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourceBatch uploaden
dc.subjectHypertensive disorders in pregnancy (HDP)en
dc.titleHypertensive disorders in pregnancy and cognitive outcomes in childhood and adolescenceen
dc.typeConference itemen
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