Determination of parameters for successful spray coating of silicon microneedle arrays

dc.contributor.authorMcGrath, Marie G.
dc.contributor.authorVrdoljak, Anto
dc.contributor.authorO'Mahony, Conor
dc.contributor.authorOliveira, Jorge C.
dc.contributor.authorMoore, Anne C.
dc.contributor.authorCrean, Abina M.
dc.contributor.funderEnterprise Irelanden
dc.contributor.funderHigher Education Authorityen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2011-07-06T14:45:45Z
dc.date.available2011-07-06T14:45:45Z
dc.date.issued2011-08-30
dc.date.updated2011-07-05T16:55:18Z
dc.description.abstractCoated microneedle patches have demonstrated potential for effective, minimally invasive, drug and vaccine delivery. To facilitate cost-effective, industrial-scale production of coated microneedle patches, a continuous coating method which utilises conventional pharmaceutical processes is an attractive prospect. Here, the potential of spray-coating silicon microneedle patches using a conventional film-coating process was evaluated and the key process parameters which impact on coating coalescence and weight were identified by employing a fractional factorial design to coat flat silicon patches. Processing parameters analysed included concentration of coating material, liquid input rate, duration of spraying, atomisation air pressure, gun-to-surface distance and air cap setting. Two film-coating materials were investigated; hydroxypropylmethylcellulose (HPMC) and carboxymethylcellulose (CMC). HPMC readily formed a film-coat on silicon when suitable spray coating parameter settings were determined. CMC films required the inclusion of a surfactant (1%, w/w Tween 80) to facilitate coalescence of the sprayed droplets on the silicon surface. Spray coating parameters identified by experimental design, successfully coated 280 μm silicon microneedle arrays, producing an intact film-coat, which follows the contours of the microneedle array without occlusion of the microneedle shape. This study demonstrates a novel method of coating microneedle arrays with biocompatible polymers using a conventional film-coating process. It is the first study to indicate the thickness and roughness of coatings applied to microneedle arrays. The study also highlights the importance of identifying suitable processing parameters when film coating substrates of micron dimensions. The ability of a fractional factorial design to identify these critical parameters is also demonstrated. The polymer coatings applied in this study can potentially be drug loaded for intradermal drug and vaccine delivery.en
dc.description.sponsorshipEnterprise Ireland (Commercialisation Fund); Higher Education Authority (Programme for Research in Third-Level Institutions); Science Foundation Ireland (National Access Programme)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMCGRATH, M. G., VRDOLJAK, A., O'MAHONY, C., OLIVEIRA, J. C., MOORE, A.C. & CREAN, A. M. 2011. Determination of parameters for successful spray coating of silicon microneedle arrays. International Journal of Pharmaceutics, 415, (1-2),pp.140-149. doi:10.1016/j.ijpharm.2011.05.064en
dc.identifier.doi10.1016/j.ijpharm.2011.05.064
dc.identifier.endpage149
dc.identifier.issn0378-5173
dc.identifier.issued1-2
dc.identifier.journaltitleInternational Journal of Pharmaceuticsen
dc.identifier.startpage140
dc.identifier.urihttps://hdl.handle.net/10468/364
dc.identifier.volume415
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0378517311005126
dc.rights© 2011 Elsevier B.V. All rights reserved.NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 2011, doi:10.1016/j.ijpharm.2011.05.064en
dc.subjectCarboxymethylcelluloseen
dc.subjectHydroxypropylmethylcelluloseen
dc.subjectSpray coaten
dc.subjectMicroneedleen
dc.subject.lcshSiliconen
dc.subject.lcshCoatingsen
dc.subject.lcshCoating processesen
dc.subject.lcshSyringesen
dc.titleDetermination of parameters for successful spray coating of silicon microneedle arraysen
dc.typeArticle (peer-reviewed)en
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