The urgent need for a harmonized severity scoring system for acute allergic reactions

dc.check.date2019-01-13
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorMuraro, Antonella
dc.contributor.authorFernandez-Rivas, Montserrat
dc.contributor.authorBeyer, Kirsten
dc.contributor.authorCardona, Victòria
dc.contributor.authorClark, Andrew T.
dc.contributor.authorEller, Esben
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorJutel, Marek
dc.contributor.authorSheikh, Aziz
dc.contributor.authorAgache, Ioana
dc.contributor.authorAllen, Katrina J.
dc.contributor.authorAngier, Liz
dc.contributor.authorBallmer-Weber, Barbara
dc.contributor.authorBilò, Maria Beatrice
dc.contributor.authorBindslev-Jensen, Carsten
dc.contributor.authorCamargo, Carlos A.
dc.contributor.authorCianferoni, Antonella
dc.contributor.authorDunn Galvin, Audrey
dc.contributor.authorEigenmann, Philippe A.
dc.contributor.authorHalken, Susanne
dc.contributor.authorHoffmann-Sommergruber, Karin
dc.contributor.authorLau, Susanne
dc.contributor.authorNilsson, Caroline
dc.contributor.authorPoulsen, Lars K.
dc.contributor.authorRueff, Franziska
dc.contributor.authorSpergel, Jonathan
dc.contributor.authorSturm, Gunter
dc.contributor.authorTimmermans, Frans
dc.contributor.authorTorres, Maria J.
dc.contributor.authorTurner, Paul
dc.contributor.authorvan Ree, Ronald
dc.contributor.authorWickman, Magnus
dc.contributor.authorWorm, Margitta
dc.contributor.authorClare Mills, E. N.
dc.contributor.authorRoberts, Graham
dc.contributor.funderFood Allergy Initiativeen
dc.contributor.funderEuropean Academy of Allergy and Clinical Immunology (EAACI)en
dc.date.accessioned2018-01-18T16:58:02Z
dc.date.available2018-01-18T16:58:02Z
dc.date.issued2018-01-13
dc.date.updated2018-01-18T15:59:20Z
dc.description.abstractThe accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that works across the range of allergenic triggers and addresses the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders’ perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that is clinically meaningful and is useful for allergy healthcare professionals and researchers; and (ii) a three grade based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice.en
dc.description.sponsorshipEuropean Academy of Allergy and Clinical Immunology (EAACI, as part of the Food Allergy and Anaphylaxis Guidelines Initiative)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMuraro, A. et al. (2018) 'The urgent need for a harmonized severity scoring system for acute allergic reactions', Allergy, 73(9), pp. 1792-1800. doi:10.1111/all.13408en
dc.identifier.doi10.1111/all.13408
dc.identifier.issn1398-9995
dc.identifier.issued9
dc.identifier.journaltitleAllergyen
dc.identifier.startpage1792
dc.identifier.startpage1800
dc.identifier.urihttps://hdl.handle.net/10468/5295
dc.identifier.volume73
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2018, EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons, Ltd. This is the peer reviewed version of the following article: Muraro, A. et al, ‘The urgent need for a harmonized severity scoring system for acute allergic reactions’, Allergy, 73(9), pp. 1792-1800, doi: 10.1111/all.13408, which has been published in final form at http://dx.doi.org/10.1111/all.13408. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectAllergic reactionsen
dc.subjectAnaphylaxisen
dc.subjectAngioedemaen
dc.subjectAsthmaen
dc.subjectDevelopmenten
dc.subjectDrug allergyen
dc.subjectFood allergyen
dc.subjectSeverity scoreen
dc.subjectUrticarialen
dc.subjectValidationen
dc.subjectVenom allergyen
dc.titleThe urgent need for a harmonized severity scoring system for acute allergic reactionsen
dc.typeArticle (peer-reviewed)en
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