Studies in the synthesis and impurity profiling of pharmacologically active benzodifurans

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dc.check.chapterOfThesisRedact Allen
dc.check.date9999-12-31
dc.check.infoRestricted Access
dc.contributor.advisorKeating, J J
dc.contributor.authorO'Connor, Richard Ericen
dc.contributor.funderHigher Education Authorityen
dc.date.accessioned2024-02-08T10:08:30Z
dc.date.available2024-02-08T10:08:30Z
dc.date.issued2022
dc.date.submitted2022
dc.description.abstractSubstituted 2,3-dihydrobenzofuran derivatives as well as their benzofuran and benzodifuranyl analogues are versatile heterocycles that are increasing in prominence as key building blocks in organic chemistry. In particular, benzodifuran-containing structures are gaining significant interest in medicinal chemistry as pharmacophores and in industrial chemistry as scaffolds for organic electroluminescent devices, organic field-effect transistors, solar cell sensitizers and semiconducting polymers. The synthesis of pharmacologically active benzodifurans are complex multi-step processes and each individual step has the potential for considerable side-product/impurity formation. This project focused on synthetic strategies to benzofuran and benzodifuran derivatives in addition to their hydrogenated and substituted analogues. The chosen synthetic routes to target molecules further focused on the propensity of synthetic steps to produce impurities, modifiable variables to modulate impurity formation and the impurity profile of each synthetic route explored. Organic process impurities identified were isolated and fully characterised where possible, in addition to intended products.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Connor, R. E. 2022. Studies in the synthesis and impurity profiling of pharmacologically active benzodifurans. PhD Thesis, University College Cork.
dc.identifier.endpage634
dc.identifier.urihttps://hdl.handle.net/10468/15532
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectHigher Education Authority (PD/2012/2652)
dc.rights© 2023, Richard Eric O'Connor.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPharmacologically active benzodifurans
dc.subjectImpurity profiling
dc.subjectKetone precurso
dc.subjectNovel Isomers
dc.subjectBenzodifuran scaffolds
dc.subjectAnti-cancer
dc.subjectRegio-specific halogenation
dc.subjectBenzodifuran ring closure
dc.titleStudies in the synthesis and impurity profiling of pharmacologically active benzodifurans
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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