Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions

dc.contributor.authorMiguel, Sophie
dc.contributor.authorChamp, Claire
dc.contributor.authorDay, Jon
dc.contributor.authorAarts, Esther
dc.contributor.authorBahr, Ben A.
dc.contributor.authorBakker, Martijntje
dc.contributor.authorBánáti, Diana
dc.contributor.authorCalabrese, Vittorio
dc.contributor.authorCederholm, Tommy
dc.contributor.authorCryan, John F.
dc.contributor.authorDye, Louise
dc.contributor.authorFarrimond, Jonathan A.
dc.contributor.authorKorosi, Aniko
dc.contributor.authorLayé, Sophie
dc.contributor.authorMaudsley, Stuart
dc.contributor.authorMilenkovic, Dragan
dc.contributor.authorMohajeri, M. Hasan
dc.contributor.authorSijben, John
dc.contributor.authorSolomon, Alina
dc.contributor.authorSpencer, Jeremy P. E.
dc.contributor.authorThuret, Sandrine
dc.contributor.authorVanden Berghe, Wim
dc.contributor.authorVauzour, David
dc.contributor.authorVellas, Bruno
dc.contributor.authorWesnes, Keith
dc.contributor.authorWillatts, Peter
dc.contributor.authorWittenberg, Raphael
dc.contributor.authorGeurts, Lucie
dc.contributor.funderInternational Life Sciences Institute Research Foundation
dc.date.accessioned2018-06-15T11:47:10Z
dc.date.available2018-06-15T11:47:10Z
dc.date.issued2018
dc.description.abstractBackground: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated. Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop 'Nutrition for the Ageing Brain: Functional Aspects and Mechanisms' in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age.en
dc.description.sponsorshipInternational Life Sciences Institute Research Foundation (Europe Nutrition and Mental Performance Task Force)en
dc.description.statusPeer reviewed
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMiquel, S., Champ, C., Day, J., Aarts, E., Bahr, B. A., Bakker, M., Bánáti, D., Calabrese, V., Cederholm, T., Cryan, J., Dye, L., Farrimond, J. A., Korosi, A., Layé, S., Maudsley, S., Milenkovic, D., Mohajeri, M. H., Sijben, J., Solomon, A., Spencer, J. P. E., Thuret, S., Vanden Berghe, W., Vauzour, D., Vellas, B., Wesnes, K., Willatts, P., Wittenberg, R. and Geurts, L. (2018) 'Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions', Ageing Research Reviews, 42, pp. 40-55. doi: 10.1016/j.arr.2017.12.004en
dc.identifier.doi10.1016/j.arr.2017.12.004
dc.identifier.endpage55
dc.identifier.issn1568-1637
dc.identifier.journaltitleAgeing Research Reviewsen
dc.identifier.startpage40
dc.identifier.urihttps://hdl.handle.net/10468/6326
dc.identifier.volume42
dc.language.isoenen
dc.publisherElsevier Ltden
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1568163717302064
dc.rights© 2017, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.subjectCognitionen
dc.subjectPreventive dieten
dc.subjectCognitive declineen
dc.subjectNeuroprotectionen
dc.subjectNeuro-inflammationen
dc.subjectPlant-food bioactivesen
dc.titlePoor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventionsen
dc.typeReviewen
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