Patients' perspectives on anti-epileptic medication: relationships between beliefs about medicines and adherence among patients with epilepsy in UK primary care

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dc.contributor.authorChapman, Sarah C. E.
dc.contributor.authorHorne, R.
dc.contributor.authorChater, A.
dc.contributor.authorHukins, D.
dc.contributor.authorSmithson, W. Henry
dc.date.accessioned2018-10-05T11:39:25Z
dc.date.available2018-10-05T11:39:25Z
dc.date.issued2014-02
dc.date.updated2018-10-05T11:30:26Z
dc.description.abstractBackground: Nonadherence to antiepileptic drugs (AEDs) can result in suboptimal outcomes for patients. Aim: This study aimed to assess the utility of a theory-based approach to understanding patient perspectives on AEDs and adherence. Method: Patients with epilepsy, identified by a GP case note review, were mailed validated questionnaires assessing their perceptions of AEDs and their adherence to them. Results: Most (84.9%) of the 398 AED-treated respondents accepted the necessity of AEDs, but over half expressed doubts, with 55% disagreeing or uncertain about the statement ‘I would prefer to take epilepsy medication than risk a seizure’. Over a third (36.4%) expressed strong concerns about the potential negative effects of AEDs. We used self-report and medication possession ratio to classify 36.4% of patients as nonadherent. Nonadherence was related to beliefs about medicines and implicit attitudes toward AEDs (p < 0.05). Adherence-related attitudes toward AEDs were correlated with general beliefs about pharmaceuticals (BMQ General: General Harm, General Overuse, and General Benefit scales) and perceptions of personal sensitivity to medicines (PSM scale). Conclusion: We identified salient, adherence-related beliefs about AEDs. Patient-centered interventions to support medicine optimization for people with epilepsy should take account of these beliefs.en
dc.description.sponsorshipHealth Foundation, United Kingdom (‘Leading Practice Through Research’ grant)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChapman, S. C. E., Horne, R., Chater, A., Hukins, D. and Smithson, W. H. (2014) 'Patients' perspectives on anti-epileptic medication: relationships between beliefs about medicines and adherence among patients with epilepsy in UK primary care', Epilepsy and Behavior, 31, pp. 312-320. doi:10.1016/j.yebeh.2013.10.016en
dc.identifier.doi10.1016/j.yebeh.2013.10.016
dc.identifier.endpage320en
dc.identifier.issn1525-5050
dc.identifier.issn1525-5069
dc.identifier.journaltitleEpilepsy and Behavioren
dc.identifier.startpage312en
dc.identifier.urihttps://hdl.handle.net/10468/6984
dc.identifier.volume31en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2013, the Authors. Published by Elsevier Inc. This article is available under the terms of the Creative Commons Attribution License (CC BY). You may distribute and copy the article, create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, including for commercial purposes without permission from Elsevier. The original work must always be appropriately credited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMedicine adherenceen
dc.subjectEpilepsyen
dc.subjectAntiepileptic drugsen
dc.subjectPrimary careen
dc.subjectPerceived Sensitivity to Medicines scaleen
dc.subjectPSMen
dc.subjectBeliefs about Medicines Questionnaireen
dc.subjectBMQen
dc.titlePatients' perspectives on anti-epileptic medication: relationships between beliefs about medicines and adherence among patients with epilepsy in UK primary careen
dc.typeArticle (peer-reviewed)en
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