Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: a systematic review and meta-analysis

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dc.contributor.authorHegarty, Shane V.
dc.contributor.authorLee, David J.
dc.contributor.authorO'Keeffe, Gerard W.
dc.contributor.authorSullivan, Aideen M.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Research Councilen
dc.contributor.funderNational University of Irelanden
dc.date.accessioned2017-02-13T14:21:08Z
dc.date.available2017-02-13T14:21:08Z
dc.date.issued2017-02-10
dc.date.updated2017-02-13T12:57:38Z
dc.description.abstractIntroduction: Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic review and meta-analysis was to determine the effects of intracerebral NTF application on motor symptoms in people with PD. Methods: We searched PubMed, MEDLINE, EMBASE, and Cochrane from inception through to March 31 2016 for open-label trials and randomized controlled trials (RCTs) which intracerebrally administered NTFs to PD patients, and which performed motor examination of Unified Parkinson's Disease Rating Scale. Results: Eight studies with a total of 223 participants were included. Fixed effects analysis revealed that NTF treatment did not significantly reduce motor symptoms in PD patients compared to placebo controls (P = 0.98). Combining open-label and RCT data, both treatment with NTFs (P < 0.001) and treatment with placebo (P < 0.05) significantly improved motor function in PD patients when compared to predicted symptoms in untreated PD controls. Finally, random effects analysis revealed that NTF-treated PD patients were not significantly likely to improve following intracerebral NTF administration (P = 0.25). Conclusion: In conclusion, intracerebral NTF administration does not improve motor symptoms in PD patients, when compared to placebo-treated controls. These findings may guide therapeutic decisions and inform future research on NTFs and their application in PD.en
dc.description.sponsorshipIrish Research Council (R15897; SVH/AS/); The National University of Ireland (R16189; SVH/AS/);en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHegarty, S. V., Lee, D. J., O'Keeffe, G. W. and Sullivan, A. M. (2017) 'Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis', Parkinsonism & Related Disorders, 38, pp.19-25 doi:10.1016/j.parkreldis.2017.02.011en
dc.identifier.doi10.1016/j.parkreldis.2017.02.011
dc.identifier.endpage25
dc.identifier.issn1353-8020
dc.identifier.journaltitleParkinsonism & Related Disordersen
dc.identifier.startpage19
dc.identifier.urihttps://hdl.handle.net/10468/3620
dc.identifier.volume38
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Career Development Award/15/CDA/3498/IE/Development of GDF5 neurotrophic factor therapy for Parkinson_s disease./
dc.rights© 2017 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectParkinson's diseaseen
dc.subjectNeurotrophic therapyen
dc.subjectClinical trialsen
dc.subjectSystematic review/meta-analysisen
dc.subjectNeurotrophic factorsen
dc.titleEffects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: a systematic review and meta-analysisen
dc.typeArticle (peer-reviewed)en
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