Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service

O'Malley, Grace Catherine

Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service

dc.check.chapterOfThesis	2,3,5,6
dc.check.embargoformat	E-thesis on CORA only	en
dc.check.opt-out	Not applicable	en
dc.check.reason	This thesis is due for publication or the author is actively seeking to publish this material	en
dc.contributor.advisor	Burls, Amanda	en
dc.contributor.advisor	Perry, Ivan J.	en
dc.contributor.advisor	Clarke, Mike	en
dc.contributor.author	O'Malley, Grace Catherine
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2016-06-23T09:05:00Z
dc.date.issued	2015
dc.date.submitted	2015
dc.description.abstract	Background: The management of childhood obesity is challenging. Aims: Thesis, i) reviews the evidence for lifestyle treatment of obesity, ii) explores cardiometabolic burden in childhood obesity, iii) explores whether changes in body composition predicts change in insulin sensitivity (IS), iv) develops and evaluates a lifestyle obesity intervention; v) develops a mobile health application for obesity treatment and vi) tests the application in a clinical trial. Methods: In Study 1, systematic reviews and meta-analyses of the 12‐month effects of lifestyle and mHealth interventions were conducted. In Study 2, the prevalence of cardiometabolic burden was estimated in a consecutive series of 267 children. In Study 3, body composition was estimated with bioelectrical impedance analysis (BIA) and dual x-ray absorptiometry (DXA) and linear regression analyses were used to estimate the extent to which each methods predicted change in IS. Study 4 describes the development of the Temple Street W82GO Healthy Lifestyle intervention for clinical obesity in children and a controlled study of treatment effect in 276 children is reported. Study 5 describes the development and testing of the Reactivate Mobile Obesity Application. Study 6 outlines the development and preliminary report from a clinical effectiveness trial of Reactivate. Results: In Study 1, meta--‐analyses BMI SDS changed by -0.16 (-0.24,‐0.07, p<0.01) and -0.03 (-0.13, 0.06, p=0.48). In study 2, cardiometabolic comorbidities were common (e.g. hypertension in 49%) and prevalence increased as obesity level increased. In Study 3, BC changes significantly predicted changes in IS. In Study 4, BMI SDS was significantly reduced in W82GO compared to controls (p<0.001). In Study 5, the Reactivate application had good usability indices and preliminary 6‐month process report data from Study 6, revealed a promising effect for Reactivate. Conclusions: W82GO and Reactivate are promising forms of treatment.	en
dc.description.sponsorship	Health Research Board (HPF 2011/54)	en
dc.description.status	Not peer reviewed	en
dc.description.version	Accepted Version
dc.format.mimetype	application/pdf	en
dc.identifier.citation	O'Malley, G.C. 2015. Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service. PhD Thesis, University College Cork.	en
dc.identifier.endpage	231	en
dc.identifier.uri	https://hdl.handle.net/10468/2772
dc.language.iso	en	en
dc.publisher	University College Cork	en
dc.rights	© 2015, Grace Catherine O'Malley.	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	en
dc.subject	Obesity	en
dc.subject	Paediatric	en
dc.subject	Telemedicine	en
dc.subject	Smartphone	en
dc.subject	Mobile health	en
dc.subject	Behavioural change	en
dc.subject	Lifestyle intervention	en
dc.subject	Cardiometabolic risk	en
dc.subject	mHealth	en
dc.thesis.opt-out	false
dc.title	Childhood obesity treatment: integrating mobile health technology into a paediatric obesity service	en
dc.type	Doctoral thesis	en
dc.type.qualificationlevel	Practitioner Doctorate	en
dc.type.qualificationname	PhD (Medicine and Health)	en
ucc.workflow.supervisor	i.perry@ucc.ie