Acoustic monitoring of lubrication and compaction effects on tablet performance using broadband acoustic resonance dissolution spectroscopy

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dc.contributor.authorPeddapatla, Raghu V. G.
dc.contributor.authorAhmed, M. Rizwan
dc.contributor.authorSousa-Gallagher, Maria J.
dc.contributor.authorKumar, Rohit
dc.contributor.authorMcSweeney, Seán
dc.contributor.authorKrüse, Jacob
dc.contributor.authorFitzpatrick, Dara
dc.contributor.authorCrean, Abina M.
dc.contributor.funderEnterprise Ireland, TC 2013-0015
dc.contributor.funderTaighde Éireann - Research Ireland, 12/RC/2275 P2
dc.contributor.funderIrish Research Council, EPSPD/2019/198
dc.date.accessioned2026-04-07T16:50:02Z
dc.date.available2026-04-07T16:50:02Z
dc.date.issued2026-04-06
dc.description.abstractroadband Acoustic Resonance Dissolution Spectroscopy (BARDS) is a novel analytical technology based on the change in the acoustic phenomena observed when a material is added into a solvent. Addition of a solid material results in the introduction of air (gas) into the solvent, which changes the compressibility of the liquid system and reduces the velocity of the sound (resonance) contained therein. In this study, the behavior of tablets in water was monitored using the BARDS technique. Tablets investigated contained 10% metoclopramide HCl (model water-soluble drug) and a microcrystalline cellulose filler and were formulated with and without a lubricant (0.5% magnesium stearate) at a range of tensile strength and porosity properties. The BARDS frequency–time profile for lubricated tablets showed an extended profile, indicating a slower wetting and prolonged displacement of gas compared to those of tablets without a lubricant. BARDS frequency–time profiles were transformed into gas volume–time profiles from which the areas under the total gas volume and volume curve (AUVC) were calculated. Lubricated tablets displayed a greater AUVC compared with unlubricated tablets. A decrease in the AUVC was observed for tablets up to the yield pressure of the formulation. For unlubricated tablets compacted at lower pressures, the gas elimination phase displayed first-order rate elimination kinetics. However, for lubricated tablets and unlubricated tablets compacted at higher pressures, two phases of gas elimination were observed: an initial fast elimination phase followed by a slower terminal elimination phase. This preliminary analysis of BARDS profiles collected demonstrates the capability of BARDS to capture differences between tablet formulations manufactured under different conditions.en
dc.description.sponsorshipEnterprise Ireland & Irish Development Agency (Project TC 2013-0015)
dc.description.sponsorshipTaighde Éireann−Research Ireland (Grant number: 12/RC/2275 P2)
dc.description.sponsorshipIrish Research Council (EPSPD/2019/198)
dc.description.versionAccepted Version
dc.format.extent11
dc.format.mimetypeapplication/pdfen
dc.identifier.authororcidPeddapatla, Raghu V. G.
dc.identifier.authororcidAhmed, M. Rizwan
dc.identifier.authororcidSousa-Gallagher, Maria J.§0000-0001-5290-8131
dc.identifier.authororcidKumar, Rohit
dc.identifier.authororcidMcSweeney, Seán
dc.identifier.authororcidKrüse, Jacob
dc.identifier.authororcidFitzpatrick, Dara§0000-0002-3626-3772
dc.identifier.authororcidCrean, Abina M.§0000-0001-6171-0303
dc.identifier.citationPeddapatla, R V G, Ahmed, M R, Sousa-Gallagher, M J, Kumar, R, McSweeney, S, Krüse, J, Fitzpatrick, D & Crean, A M 2026, 'Acoustic monitoring of lubrication and compaction effects on tablet performance using broadband acoustic resonance dissolution spectroscopy', Molecular Pharmaceutics, vol. 23, no. 4, pp. 2319-2329. https://doi.org/10.1021/acs.molpharmaceut.5c01170
dc.identifier.doi10.1021/acs.molpharmaceut.5c01170
dc.identifier.endpage2329
dc.identifier.issn1543-8384
dc.identifier.issued4
dc.identifier.journaltitleMolecular Pharmaceutics
dc.identifier.othercrossref: 10.1021/acs.molpharmaceut.5c01170
dc.identifier.otherORCID: /0000-0001-5290-8131/work/211020610
dc.identifier.otherORCID: /0000-0001-6171-0303/work/211021300
dc.identifier.otherORCID: /0000-0002-3626-3772/work/211021678
dc.identifier.startpage2319
dc.identifier.urihttps://hdl.handle.net/10468/18684
dc.identifier.volume23
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.urihttps://www.scopus.com/pages/publications/105035006815
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c01170
dc.rights© 2026, theAuthors. Published by American Chemical Society.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectBARDS
dc.subjectDirect compression
dc.subjectDisintegration
dc.subjectDissolution
dc.subjectLubrication
dc.subjectMagnesium stearate
dc.subjectTablet compaction
dc.subject[Chemistry]
dc.subject[EngineeringArchitecture]
dc.subject[Pharmacy]
dc.titleAcoustic monitoring of lubrication and compaction effects on tablet performance using broadband acoustic resonance dissolution spectroscopyen
dc.typeArticle (peer-reviewed)
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