Micro cameras as adjunct tools in biomedical applications

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dc.contributor.advisorAndersson-Engels, Stefan
dc.contributor.advisorBurke, Ray
dc.contributor.advisorSorensen, Simon Toft
dc.contributor.authorNiemitz, Lorenzoen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2024-09-17T10:55:13Z
dc.date.available2024-09-17T10:55:13Z
dc.date.issued2024
dc.date.submitted2024
dc.description.abstractBiomedical imaging is one of the most impactful periprocedural tools and is used across a wide range medical applications. The eyes of the clinician are a key component in surgical decision making, and an image is often the first step in both diagnostic and interventional procedures. With the miniaturisation of CMOS image sensors, micro-cameras are being investigated for use in biomedical imaging and the development of biomedically specific sensors has begun. This thesis makes several important contributions to the use of these micro-cameras as adjunct tools that meet a number of unmet clinical needs in a variety of interventional procedures. To achieve this integration capabilities are demonstrated and a micro-camera based technology platform is developed. The micro-camera is integrated at the tip of various devices, along with multi-spectral fibre illumination, automated readout, control, and image processing; into a compact format suitable for clinical use. The technology is then applied to a number of applications, with the system tailored to the specific use cases. The verification of procedural success in a cardiovascular intervention is investigated. A micro-camera based 2.30 mm catheter device is developed and tested on an animal model. It is shown to be able to image in the challenging environment of the blood field. Here the procedure can be recorded and we are able to extract physiological information in a step toward verification of device placement as well as success of ablation procedures in the heart. The dimensions are pushed to 1.19 mm to navigate into the peripheral lung. This achieves imaging deeper than with a traditional bronchoscope, while maintaining the ability to provide multi-spectral illumination via fibre optics. This is demonstrated on ex-vivo tissue. The micro-camera platform makes an impact on breast conserving surgery procedures, where for the first time the periprocedural imaging of micro-calcifications is investigated. This enables the intra-surgical detection of micro-calcifications up to 2.00 mm in the resection margin. To do this a multi-spectral diffuse optical imaging technique for surgical guidance is proposed, and used to detect micro-calcifications. A rigorous co-registration method is developed to validate the data, and image processing techniques proposed to aid the automated detection. Finally, polarisation resolved imaging is investigated using the microcamera. Here the platform offers a solution for flexible polarisation resolved imaging systems. An initial prototype of both a miniature and benchtop system is presented along with images on optical elements and bulk tissue samples. Line of sight to tissue imaging, and to investigate multi-spectral polarisation resolved imaging is discussed.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNiemitz, L. 2024. Micro cameras as adjunct tools in biomedical applications. PhD Thesis, University College Cork.
dc.identifier.endpage227
dc.identifier.urihttps://hdl.handle.net/10468/16376
dc.language.isoenen
dc.publisherUniversity College Corken
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres Programme::Phase 2/12/RC/2276_P2/IE/IPIC_Phase 2/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme::Second-Term Funding/22/RP-2TF/10293/IE/Biophotonics@Tyndall phase 2 - Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.rights© 2024, Lorenzo Niemitz.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMicro camera
dc.subjectEndoscopy
dc.subjectImaging
dc.subjectCMOS image sensor
dc.subjectMiniaturisation
dc.titleMicro cameras as adjunct tools in biomedical applicationsen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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