Recent trends in whole cell and isolated enzymes in enantioselective synthesis
Milner, Sinéad E.
Maguire, Anita R.
Modern synthetic organic chemistry has experienced an enormous growth in biocatalytic methodologies; enzymatic transformations and whole cell bioconversions have become generally accepted synthetic tools for asymmetric synthesis. This review details an overview of the latest achievements in biocatalytic methodologies for the synthesis of enantiopure compounds with a particular focus on chemoenzymatic synthesis in non-aqueous media, immobilisation technology and dynamic kinetic resolution. Furthermore, recent advances in ketoreductase technology and their applications are also presented.
Biocatalysis , Kinetic resolution , Dynamic kinetic resolution , Baker’s yeast , Ketoreductases
S.E. MILNER, AND A.R. MAGUIRE.; 2012. Recent trends in whole cell and isolated enzymes in enantioselective synthesis. Arkivoc, 321-382.