Assessment of plasma B7-H3 levels in pediatric patients with different degrees of surgical stress

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dc.contributor.authorLi, Yan
dc.contributor.authorYuan, Qing
dc.contributor.authorHuang, Jie
dc.contributor.authorLi, Yi Ping
dc.contributor.authorPan, Jian
dc.contributor.authorFeng, Xing
dc.contributor.authorZhang, Xue Guang
dc.contributor.authorWang, Jiang Huai
dc.contributor.authorWang, Jian
dc.contributor.funderKey Laboratory of Suzhou, China
dc.contributor.funderJiangsu Province Program of Innovative and Entrepreneurial Talents
dc.contributor.funderNational Natural Science Foundation of China
dc.contributor.funderInnovative Team of Jiangsu Province
dc.date.accessioned2017-06-20T11:39:46Z
dc.date.available2017-06-20T11:39:46Z
dc.date.issued2016-07-26
dc.description.abstractBackground: Surgical stress initiates a series of host hormone, metabolism and immune responses, which predominantly affect the homeostatic mechanism of patients with major surgery. B7-H3 is a co-stimulatory molecule and has been shown to participate in both adaptive and innate immune responses. In this study we evaluated the clinical significance of plasma B7-H3 levels in pediatric patients with different types of operation and degrees of surgical stress. Methods: A total of 48 children received pediatric general and cardiac surgery were recruited into this study. Based on the surgical stress scoring, children were divided into moderate stress (n?=?14) and severe stress (n?=?34) groups. Plasma B7-H3 levels were assessed at selected time points: before surgery, immediately after surgery, at day 1, day 3, and day 7 after surgery. Correlations between plasma B7-H3 levels and surgical stress scores were also examined. Results: Plasma B7-H3 levels were significantly decreased in all 48 pediatric patients after surgery compared to the B7-H3 level before surgery (p?<?0.01). Children with general surgery showed significant decreases in plasma B7-H3 immediately after surgery, and at day 3 and day 7 after surgery (p?<?0.05, p?<?0.01), whereas children with cardiac surgery showed reduced plasma B7-H3 immediately after surgery and at day 3 after surgery (p?<?0.05). Plasma B7-H3 in cardiac surgery group was dropped much lower than that in general surgery group at day 1 (p?<?0.05) and day 3 (p?<?0.01) after surgery. Significantly reduced plasma B7-H3 was observed in the severe stress group, but not in the moderate stress group, immediately after surgery and at day 3 after surgery (p?<?0.05), and severe stress group had significantly lower plasma B7-H3 levels than moderate stress group at day 1, day 3, and day 7 after surgery (p?<?0.05). Furthermore, plasma B7-H3 levels at day 1 (p?=?0.01) and day 3 (p?=?0.025) after surgery correlated negatively with surgical stress scores. Conclusions: Plasma B7-H3 levels were decreased significantly in children subjected to pediatric general and cardiac surgery, which is closely associated with the severity of surgical stress. The negative correlation of plasma B7-H3 levels at day 1 and day 3 after surgery with surgical stress scoring implicates that the plasma B7-H3 level might be a useful biomarker for monitoring stress intensity during pediatric surgery.en
dc.description.sponsorshipNational Natural Science Foundation of China (Grant 81272143 and 81420108022); Key Laboratory of Suzhou (Grant SZS201307); Innovative Team of Jiangsu Province (Grant LJ201141); Jiangsu Province Program of Innovative and Entrepreneurial Talents (2011–2014).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid110
dc.identifier.citationLi, Y., Yuan, Q., Huang, J., Li, Y. P., Pan, J., Feng, X., Zhang, X. G., Wang, J. H. and Wang, J. (2016) 'Assessment of plasma B7-H3 levels in pediatric patients with different degrees of surgical stress', BMC Pediatrics, 16,110 (6pp). doi: 10.1186/s12887-016-0655-1en
dc.identifier.doi10.1186/s12887-016-0655-1
dc.identifier.endpage6
dc.identifier.issn1471-2431
dc.identifier.journaltitleBMC Pediatricsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/4115
dc.identifier.volume16
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urihttps://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-016-0655-1
dc.rights© 2016, Li et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPediatric surgeryen
dc.subjectB7-H3en
dc.subjectSurgical stressen
dc.subjectChildrenen
dc.titleAssessment of plasma B7-H3 levels in pediatric patients with different degrees of surgical stressen
dc.typeArticle (peer-reviewed)en
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