Major structure-activity relationships of resolvins, protectins, maresins and their analogues
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Accepted Version
Date
2022-11-30
Authors
Daly, Kevin
O'Sullivan, Killian
O'Sullivan, Timothy P.
Journal Title
Journal ISSN
Volume Title
Publisher
Future Science Ltd
Published Version
Abstract
Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response. These molecules are currently the focus of intensive investigation, primarily for their ability to suppress inflammation in chronic disease states. Researchers have employed different synthetic approaches to assess whether various structural modifications of these compounds could provide access to future therapeutics. This review summarizes the modifications made thus far and focuses on the key structure-activity relationships which have been uncovered for resolvins, protectins, maresins and their analogues.
Description
Keywords
Drug design , Inflammation , Maresins , Polyunsaturated fatty acids , Protectins , Resolvins
Citation
Daly, K., O'Sullivan, K. and O'Sullivan, T. P. (2022) 'Major structure-activity relationships of resolvins, protectins, maresins and their analogues', Future Medicinal Chemistry, 14(24), pp. 1943-1960. doi: 10.4155/fmc-2022-0206
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© 2022, Future Science Ltd. All rights reserved.