A retrospective study of outcome predictive models for anterior circulation stroke post-endovascular thrombectomy: Are CT-derived morphomics useful?

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dc.contributor.authorManole, Constantin
dc.contributor.authorShet, Sahil
dc.contributor.authorO'Brien, Alan
dc.contributor.authorKakish, Eid
dc.contributor.authorO'Regan, Patrick
dc.contributor.authorMaher, Michael M.
dc.contributor.authorKelly, Roisin
dc.contributor.authorHegarty, Aidan
dc.contributor.authorFanning, Noel
dc.contributor.authorRyan, David J.
dc.date.accessioned2026-09-18T15:29:01Z
dc.date.available2026-09-18T15:29:01Z
dc.date.issued2026-06-13
dc.description.abstractIntroduction: In acute ischaemic stroke secondary to a large vessel occlusion, endovascular thrombectomy (EVT) is the standard of care. However, prediction of functional outcomes following EVT remains challenging. We sought to determine whether CT-derived morphomic data on body composition can improve outcome prediction following EVT. Methods: A retrospective analysis of anterior circulation stroke patients who underwent EVT between 2021 and 2023 at a single centre was conducted. Demographic, clinical, and morphomic data including neck muscle and fat area and density were collected. Multivariate logistic regression was used to develop pre-procedure and 24-h post-EVT models for predicting 90-day outcomes. A positive outcome was defined as a modified Rankin Scale (mRS) score of ≤2 at 90 days post-EVT. These models were subsequently tested on 2 separate validation cohorts. Results: High pre-procedure ASPECTS scores, lower baseline NIHSS scores, absence of post-procedure haemorrhage, younger age, and early neurological improvement were the strongest predictors of a positive outcome. None of the morphomic variables were significantly correlated with outcome. The 24-h model was highly accurate in predicting post-EVT outcomes in both validation cohorts. Conclusion: CT-derived morphomic variables did not significantly improve prediction of stroke outcomes post-EVT. Clinical and imaging variables (especially 24-h post-procedure data) showed high accuracy in predicting functional outcomes at 90 days.en
dc.description.versionPublished Version
dc.format.extent14
dc.format.mimetypeapplication/pdfen
dc.identifier.authororcidManole, Constantin
dc.identifier.authororcidShet, Sahil
dc.identifier.authororcidO'Brien, Alan
dc.identifier.authororcidKakish, Eid
dc.identifier.authororcidO'Regan, Patrick
dc.identifier.authororcidMaher, Michael M.
dc.identifier.authororcidKelly, Roisin§0000-0002-6379-9943
dc.identifier.authororcidHegarty, Aidan
dc.identifier.authororcidFanning, Noel
dc.identifier.authororcidRyan, David J.§0000-0001-8906-2379
dc.identifier.citationManole, C, Shet, S, O'Brien, A, Kakish, E, O'Regan, P, Maher, M M, Kelly, R, Hegarty, A, Fanning, N & Ryan, D J 2026, 'A retrospective study of outcome predictive models for anterior circulation stroke post-endovascular thrombectomy : Are CT-derived morphomics useful?', Acta Cytologica, vol. 16, no. 1, pp. 180-193. https://doi.org/10.1159/000550274
dc.identifier.doi10.1159/000550274
dc.identifier.endpage193
dc.identifier.issn0001-5547
dc.identifier.issued1
dc.identifier.journaltitleActa Cytologica
dc.identifier.otherORCID: /0000-0002-6379-9943/work/227181883
dc.identifier.startpage180
dc.identifier.urihttps://hdl.handle.net/10468/19297
dc.identifier.volume16
dc.language.isoen
dc.publisherS. Karger AG
dc.relation.urihttps://www.scopus.com/pages/publications/105046433965
dc.rights© 2026 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (https:// karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.statusPeer reviewed
dc.subjectAnterior circulation stroke
dc.subjectEndovascular thrombectomy
dc.subjectMorphomics
dc.subjectRisk prediction
dc.subject[Medicine]
dc.subject[Pharmacy]
dc.titleA retrospective study of outcome predictive models for anterior circulation stroke post-endovascular thrombectomy: Are CT-derived morphomics useful?en
dc.typeArticle (peer-reviewed)
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