Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countries

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dc.contributor.authorRoth, Daniel E.
dc.contributor.authorAbrams, Steven A.
dc.contributor.authorAloia, John
dc.contributor.authorBergeron, Gilles
dc.contributor.authorBourassa, Megan W.
dc.contributor.authorBrown, Kenneth H.
dc.contributor.authorCalvo, Mona S.
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorCombs, Gerald
dc.contributor.authorDe-Regil, Luz María
dc.contributor.authorJefferds, Maria Elena
dc.contributor.authorJones, Kerry S.
dc.contributor.authorKapner, Hallie
dc.contributor.authorMartineau, Adrian R.
dc.contributor.authorNeufeld, Lynnette M.
dc.contributor.authorSchleicher, Rosemary L.
dc.contributor.authorThacher, Tom D.
dc.contributor.authorWhiting, Susan J.
dc.contributor.funderBill and Melinda Gates Foundationen
dc.date.accessioned2019-10-01T05:12:22Z
dc.date.available2019-10-01T05:12:22Z
dc.date.issued2018-09-18
dc.description.abstractAbstract Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency–related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. However, efforts to assess the vitamin D status of populations in low- and middle-income countries have been hampered by limited availability of population-representative 25(OH)D data, particularly among population subgroups most vulnerable to the skeletal and potential extraskeletal consequences of low vitamin D status, namely exclusively breastfed infants, children, adolescents, pregnant and lactating women, and the elderly. In the absence of 25(OH)D data, identification of communities that would benefit from public health interventions to improve vitamin D status may require proxy indicators of the population risk of vitamin D deficiency, such as the prevalence of rickets or metrics of usual UVB exposure. If a high prevalence of vitamin D deficiency is identified (>20% prevalence of 25(OH)D < 30 nmol/L) or the risk for vitamin D deficiency is determined to be high based on proxy indicators (e.g., prevalence of rickets >1%), food fortification and/or targeted vitamin D supplementation policies can be implemented to reduce the burden of vitamin D deficiency–related conditions in vulnerable populations.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRoth, D.E., Abrams, S.A., Aloia, J., Bergeron, G., Bourassa, M.W., Brown, K.H., Calvo, M.S., Cashman, K.D., Combs, G., De‐Regil, L.M. and Jefferds, M.E., 2018. Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐and middle‐income countries. Annals of the New York Academy of Sciences, 1430(1), (35pp). DOI:10.1111/nyas.13968en
dc.identifier.doi10.1111/nyas.13968en
dc.identifier.eissn1749-6632
dc.identifier.endpage79en
dc.identifier.issn0077-8923
dc.identifier.issued12en
dc.identifier.journaltitleAnnals of the New York Academy of Sciencesen
dc.identifier.startpage44en
dc.identifier.urihttps://hdl.handle.net/10468/8647
dc.identifier.volume1430en
dc.language.isoenen
dc.publisherBlackwell Publishing Inc.en
dc.relation.urihttps://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/nyas.13968
dc.rights© 2018 The Authors.Annals of the New York Academy of Sciencespublished by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectVitamin Den
dc.subject25-hydroxyvitamin Den
dc.subjectCholecalciferoen
dc.subjectRicketsen
dc.subjectDeveloping countriesen
dc.subjectMicronutrientsen
dc.subjectNutritionen
dc.subjectDietary supplementationen
dc.subjectFortificationen
dc.titleGlobal prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countriesen
dc.typeArticle (peer-reviewed)en
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