Novel insights into the inflammatory basis of gastrointestinal disease

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dc.check.date10000-01-01
dc.check.embargoformatBoth hard copy thesis and e-thesisen
dc.check.entireThesisEntire Thesis Restricted
dc.check.infoIndefiniteen
dc.check.opt-outYesen
dc.check.reasonReleasing this thesis would cause substantial prejudice to the commercial interests of the sponsor of the postgraduate researchen
dc.contributor.advisorNally, Kennethen
dc.contributor.advisorCryan, John F.en
dc.contributor.authorMoloney, Gerard M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2014-06-18T11:35:32Z
dc.date.issued2013
dc.date.submitted2013
dc.description.abstractIt has become clear that inflammation is beneficial to man, there are situations though that the inflammatory response causes damage to the host that is harmful to health. When the inflammatory response fails or is too strong, the health of the host is damaged and disease can occur. The implication of intestinal disease caused by an ineffective immune response is of great social and economic burden to society. The overarching purpose of this thesis is to assess inflammatory signalling targets associated with immune mediated disorders such as IBD, IBS and inflammatory liver disease. By assessing these targets and modifying their function I hope to contribute and expand further the pre-existing information on these disorders and improve the therapeutic interventions available in these debilitating conditions. I will assess the role of inflammation in disorders of the GI tract and liver IBD, IBS, hepatic inflammatory injury and furthermore, I will use pharmaceutical agents to activate and suppress components of the immune system. I will examine the inflammatory response in experimental models of disease for IBD and liver injury, I will attempt to alter these pathways using pharmaceutical intervention to delineate the disease causing mechanism that may lead to clinically relevant therapeutic interventions. In regards to IBS, I will attempt to improve the existing knowledge that exists in relation to the pathogenesis of this functional bowel disorder. I will attempt to define a mechanism by which the low grade mucosal inflammation that has been demonstrated by others arises and what this inflammation is induced by. The overall aim of this thesis is to attempt to further understand the mechanisms behind GI and liver disease. Looking at the inflammatory response in these specific conditions and how they can be altered may lead to exciting new therapies for inflammatory conditions in the gastrointestinal tract.en
dc.description.sponsorshipScience Foundation Ireland (02/CE/B124); Science Foundation Ireland (07/CE/B1368)en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMoloney, G. 2013. Novel insights into the inflammatory basis of gastrointestinal disease. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/1579
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2013, Gerard Moloney.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectInflammationen
dc.subjectEpigeneticsen
dc.subjectBromodomainen
dc.subjectInterferonen
dc.subjectMucosal immunityen
dc.subjectNuclear receptorsen
dc.subjectInflammatory bowel diseaseen
dc.subjectIrritable bowel syndromeen
dc.thesis.opt-outtrue
dc.titleNovel insights into the inflammatory basis of gastrointestinal diseaseen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD (Medicine and Health)en
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