Effect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trial

dc.check.date2023-02-17
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorO'Sullivan, Laura
dc.contributor.authorGallagher, Catherine
dc.contributor.authorNí­ Ríordáin, Richeal
dc.date.accessioned2022-03-02T15:52:40Z
dc.date.available2022-03-02T15:52:40Z
dc.date.issued2022-02-17
dc.date.updated2022-03-02T15:39:49Z
dc.description.abstractThe objective of this study was to investigate the effect of plasma rich in growth factors (PRGF) on patient- and clinician-reported outcomes following mandibular third molar removal. Seventy-four patients requiring surgical removal of a unilateral impacted mandibular third molar under local anaesthesia were recruited into the study. PRGF was prepared for all patients irrespective of study arm allocation. Reviews were conducted 3 days (T1) and 7 days (T2) postoperatively. Primary outcome measures were pain (numerical rating scale, NRS), OHIP-14 (Oral Health Impact Profile-14), and postoperative symptom severity scale (PoSSe) data. Secondary outcome measures including mouth opening, dry socket, socket healing, and analgesic consumption were also explored. The statistical analysis was performed using analysis of covariance and the χ2 test. NRS pain scores were higher in the PRGF group at T1, demonstrating borderline significance (mean difference 1.0; P = 0.06), with no difference at T2. PoSSe scores did not differ between the groups, with the exception of the ‘interference with daily activities’ subscale at T1, where PRGF group patients scored 1.2 units higher (P = 0.02). OHIP-14 scores demonstrated a 25% increased likelihood of PRGF patients reporting discomfort on eating at T1 (P = 0.02), with no statistical significance at T2. Secondary outcomes did not differ between the groups. No difference in clinical or quality of life outcomes was observed for patients receiving adjunctive PRGF in third molar sockets.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationO'Sullivan, L., Gallagher, C. and Ní Rí­ordáin, R. (2022) 'Effect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trial', International Journal of Oral and Maxillofacial Surgery. doi: 10.1016/j.ijom.2022.02.003en
dc.identifier.doi10.1016/j.ijom.2022.02.003en
dc.identifier.eissn1399-0020
dc.identifier.issn0901-5027
dc.identifier.journaltitleInternational Journal of Oral and Maxillofacial Surgeryen
dc.identifier.urihttps://hdl.handle.net/10468/12693
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2022, International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectThird molaren
dc.subjectWisdom teethen
dc.subjectPlatelet-rich plasmaen
dc.subjectQuality of lifeen
dc.subjectPlatelet-rich fibrinen
dc.subjectPlasmaen
dc.subjectRandomized controlled trialen
dc.titleEffect of plasma rich in growth factors on quality of life following mandibular third molar removal: a double-blind randomized controlled trialen
dc.typeArticle (peer-reviewed)en
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