Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition

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dc.contributor.authorReen, F. Jerry
dc.contributor.authorGutiérrez-Barranquero, José A.
dc.contributor.authorParages, María L.
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderEnterprise Ireland
dc.contributor.funderTeagasc
dc.contributor.funderMarine Institute
dc.contributor.funderIrish Thoracic Society
dc.contributor.funderHealth Research Board
dc.contributor.funderIrish Research Council for Science, Engineering and Technology
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderEuropean Commission
dc.date.accessioned2018-02-20T13:24:15Z
dc.date.available2018-02-20T13:24:15Z
dc.date.issued2018
dc.description.abstractAntibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinical effectiveness of conventional antibiotics. An intricate cell-cell communication system termed quorum sensing (QS) and the coordinated multicellular behaviour of biofilm formation have both been identified as promising targets for the treatment and clinical management of microbial infections. QS systems allow bacteria to adapt rapidly to harsh conditions, and are known to promote the formation of antibiotic tolerant biofilm communities. It is well known that biofilm is a recalcitrant mode of growth and it also increases bacterial resistance to conventional antibiotics. The pharmacological properties of coumarins have been well described, and these have included several that possess antimicrobial properties. More recently, reports have highlighted the potential role of coumarins as alternative therapeutic strategies based on their ability to block the QS signalling systems and to inhibit the formation of biofilms in clinically relevant pathogens. In addition to human infections, coumarins have also been found to be effective in controlling plant pathogens, infections in aquaculture, food spoilage and in reducing biofouling caused by eukaryotic organisms. Thus, the coumarin class of small molecule natural product are emerging as a promising strategy to combat bacterial infections in the new era of antimicrobial resistance.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (FIRM/RSF/CoFoRD; FIRM 08/RDC/629; FIRM 1/F009/ MabS; FIRM 13/F/516); Irish Research Council for Science, Engineering and Technology (PD/2011/2414; GOIPG/2014/647); Health Research Board/Irish Thoracic Society (MRCG-2014-6); the Marine Institute (Beaufort award C2CRA 2007/082); Teagasc (Walsh Fellowship 2013); Enterprise Ireland (CF-2017-0757-P).en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationReen, F. J., Gutiérrez-Barranquero, J. A., Parages, M. L. and O'Gara, F. (2018) 'Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition', Applied Microbiology and Biotechnology, 102(5), pp. 2063–2073. doi: 10.1007/s00253-018-8787-xen
dc.identifier.doi10.1007/s00253-018-8787-x
dc.identifier.endpage11
dc.identifier.issn0175-7598
dc.identifier.issn1432-0614
dc.identifier.journaltitleApplied Microbiology and Biotechnologyen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/5523
dc.language.isoenen
dc.publisherSpringer International Publishing AGen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEA
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATION
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2977/IE/Pre-clinical testing of novel fungal biofilm blockers for the medical device sector./
dc.relation.urihttps://link.springer.com/article/10.1007%2Fs00253-018-8787-x
dc.rights© 2018, the Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCoumarinen
dc.subjectQuorum sensing inhibitionen
dc.subjectAntibiofilmen
dc.subjectAnti-infectivesen
dc.subjectNatural productsen
dc.titleCoumarin: a novel player in microbial quorum sensing and biofilm formation inhibitionen
dc.typeArticle (peer-reviewed)en
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