Development of stabilized vaccines with needle-free devices for targeted skin immunization

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dc.contributor.authorMoore, Anne C.
dc.contributor.authorCrean, Abina M.
dc.contributor.authorO'Mahony, Conor
dc.contributor.editorDifford, Helen
dc.date.accessioned2011-05-17T10:21:30Z
dc.date.available2011-05-17T10:21:30Z
dc.date.issued2010-12
dc.date.updated2011-04-20T13:57:15Z
dc.description.abstractVaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMOORE, A. C., CREAN, A. M. & O'MAHONY, C. 2010. Development of stabilized vaccines with needle-free devices for targeted skin immunization. European Pharmaceutical Review, 15(6), pp. 56-60.en
dc.identifier.endpage60en
dc.identifier.issn1759-1279
dc.identifier.issued6en
dc.identifier.journaltitleEuropean Pharmaceutical Reviewen
dc.identifier.startpage56en
dc.identifier.urihttps://hdl.handle.net/10468/306
dc.identifier.volume15en
dc.language.isoenen
dc.publisherRussell Publishing Limiteden
dc.relation.urihttp://www.europeanpharmaceuticalreview.com/
dc.rights©European Pharmaceutical Reviewen
dc.subjectVaccine deliveryen
dc.subjectMicroneedleen
dc.subject.lcshImmunizationen
dc.titleDevelopment of stabilized vaccines with needle-free devices for targeted skin immunizationen
dc.typeArticle (non peer-reviewed)en
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