A Rasmussen Encephalitis in an adolescent girl

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dc.contributor.authorSankar, Shreyaen
dc.contributor.editorMehta, Shobhaen
dc.contributor.editorCronin, Pádraigen
dc.date.accessioned2025-10-28T13:55:01Z
dc.date.available2025-10-28T13:55:01Z
dc.date.issued2025en
dc.description.abstractIntroduction: A 12-year-old female presented to clinic with various features of cognitive decline, including headaches, worsening academic performance, and decline in writing abilities and social skills. On neurological examination, she was found to have intrinsic muscle weakness in the right hand, reduced grip and wrist extension of the right arm, pronator drift of the right arm, and left hemiglossal atrophy, along with lessened spontaneous speech abilities. She had no dysarthria, sensory loss, or reduction of tone. The differential diagnoses considered for this patient were chronic viral encephalitis and autoimmune encephalitis. Case Report: Initial tests included serology (Full Blood Count and IgG Antibody) and cerebrospinal fluid (CSF) analysis, both of which were unremarkable. Angiography results were also normal. Magnetic Resonance Imaging (MRI) depicted left cerebral hemisphere atrophy and T2 hyperintensity in the frontal lobe. Electrophoresis and flow cytometry were not indicative of oligoclonal bands or NMDA-receptor antibodies. Most interestingly, routine EEG did not demonstrate epileptic activity (the hallmark sign of RE), but right-sided amplitude predominance indicated left hemispheric dysfunction. Surgical intervention involved a biopsy of the anterior middle frontal gyrus. The biopsy depicted CD45+ T-cell lymphocyte infiltration, microglial nodules, cortical atrophy, neuronal loss, and cyten
dc.description.statusNot peer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSankar, S. (2025) 'A Rasmussen Encephalitis in an adolescent girl', UCC Student Medical Journal, 5, p.95. https://doi.org/10.33178/SMJ.2025.1.22en
dc.identifier.doi10.33178/SMJ.2025.1.22en
dc.identifier.endpage95en
dc.identifier.issn2737-7237
dc.identifier.journalabbrevUCC SMJ
dc.identifier.journaltitleUCC Student Medical Journalen
dc.identifier.startpage95en
dc.identifier.urihttps://hdl.handle.net/10468/18099
dc.identifier.volume5
dc.language.isoenen
dc.publisherUCC Medical Research and Technology Societyen
dc.rights© 2025, the Author(s). This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.sourceBatch uploaden
dc.subjectImmunosuppressive therapyen
dc.subjectPaediatric Rasmussen encephalitisen
dc.titleA Rasmussen Encephalitis in an adolescent girlen
dc.typeConference itemen
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