Organolithium bases in flow chemistry: a review

dc.contributor.authorPower, Mark
dc.contributor.authorAlcock, Emma
dc.contributor.authorMcGlacken, Gerard P.
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2020-05-15T09:40:21Z
dc.date.available2020-05-15T09:40:21Z
dc.date.issued2020-04-30
dc.date.updated2020-05-15T09:32:11Z
dc.description.abstractFlow chemistry is a continually emerging and ever-growing area of synthetic organic chemistry. It provides an orthogonal approach to traditional batch chemistry, oftentimes allowing for more efficient routes to desired target molecules. It is generally accepted that flow chemistry offers a valuable change to the process landscape. From a process perspective, there are many advantages associated with flow chemistry over traditional batch chemistry, the most prominent of which is an increased safety profile with the use of highly reactive chemical species, such as organolithiums. These reagents are highly valuable species for the efficient synthesis of pharmaceutical intermediates. Disadvantageously, use of these reagents on commercial scale is severely hindered by the highly energetic nature of the reaction intermediates and their concomitant safety risk. Flow chemistry provides a viable platform for use of these reagents, offering a high degree of control over reaction parameters. In this review, we present a comprehensive account of the published literature implementing the use of organolithium reagents as strong bases for deprotonation reactions in flow systems.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPower, M., Alcock, E., and McGlacken, G. P. (2020) 'Organolithium Bases in Flow Chemistry: A Review', Organic Process Research & Development, doi: 10.1021/acs.oprd.0c00090en
dc.identifier.doi10.1021/acs.oprd.0c00090en
dc.identifier.eissn1520-586X
dc.identifier.endpage46en
dc.identifier.issn1083-6160
dc.identifier.journaltitleOrganic Process Research & Developmenten
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9956
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acs.oprd.0c00090
dc.rights© 2020 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research and Development, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.oprd.0c00090en
dc.subjectFlowen
dc.subjectChemistryen
dc.subjectOrganolithiumen
dc.subjectBaseen
dc.subjectDeprotonationen
dc.subjectReagentsen
dc.subjectChemical reactionsen
dc.subjectOrganic compoundsen
dc.subjectFluid dynamicsen
dc.titleOrganolithium bases in flow chemistry: a reviewen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
12744_acs.oprd.0c00090.pdf
Size:
728.77 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description: