Is there potential for repurposing statins as novel antimicrobials?

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dc.contributor.authorHennessy, Emma
dc.contributor.authorAdams, Claire
dc.contributor.authorReen, F. Jerry
dc.contributor.authorO'Gara, Fergal
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderFood Institutional Research Measureen
dc.date.accessioned2019-11-05T17:06:13Z
dc.date.available2019-11-05T17:06:13Z
dc.date.issued2016-08-22
dc.date.updated2019-11-05T17:00:27Z
dc.description.abstractStatins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, and antimicrobial effects. An increasing number of studies are emerging which detail the attenuation of bacterial growth and in vitro and in vivo virulence by statin treatment. In this review, we describe the current information available concerning the effects of statins on bacterial infections and provide insight regarding the potential use of these compounds as antimicrobial therapeutic agents.en
dc.description.sponsorshipHealth Research Board (HRB MRCG-2014-6)en
dc.description.sponsorshipTeagasc (Walsh Fellowship 2013)en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (FIRM/RSF/CoFoRD, FIRM 08/RDC/629, FIRM 1/F009/MabS, and FIRM 13/F/516)en
dc.description.sponsorshipIrish Research Council for Science, Engineering and Technology (PD/2011/2414 and GOIPG/2014/647))en
dc.description.sponsorshipMarine Institute ((Foras Na Mara) (Beaufort award C2CRA 2007/082))en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHennessy, E., Adams, C., Reen, F. J. and O'Gara, F. (2016) 'Is There Potential for Repurposing Statins as Novel Antimicrobials?', Antimicrobial Agents and Chemotherapy, 60(9), pp. 5111-5121. doi: 10.1128/AAC.00192-16en
dc.identifier.doi10.1128/AAC.00192-16en
dc.identifier.endpage21en
dc.identifier.issn1098-6596
dc.identifier.issued9en
dc.identifier.journaltitleAntimicrobial Agents and Chemotherapy,en
dc.identifier.startpage5111en
dc.identifier.urihttps://hdl.handle.net/10468/8956
dc.identifier.volume60en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAINen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBAen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/256596/EU/Dissecting the role of a novel transcriptional regulator in microbial-host interactomes./MEXT REGULATIONen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMAREen
dc.relation.urihttps://aac.asm.org/content/60/9/5111.short
dc.rights© 2016, American Society for Microbiology. All Rights Reserved.en
dc.subjectAnti-infective agentsen
dc.subjectBacteremiaen
dc.subjectBacterial toxinsen
dc.subjectBiofilmsen
dc.subjectDrug repositioningen
dc.subjectGram-negative bacteriaen
dc.subjectGram-positiveen
dc.subjectBacteriaen
dc.subjectHydroxymethylglutaryl-CoA reductase inhibitorsen
dc.subjectMicrobial sensitivityen
dc.subjectTestsen
dc.subjectPneumonia, bacterialen
dc.subjectSepsisen
dc.subjectSurvival analysisen
dc.subjectVirulence factorsen
dc.titleIs there potential for repurposing statins as novel antimicrobials?en
dc.typeArticle (peer-reviewed)en
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