Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines

dc.check.date10000-01-01T10:39:47Z
dc.check.embargoformatE-thesis on CORA onlyen
dc.check.entireThesisEntire Thesis Restricted
dc.check.infoRestricted to everyone indefinitelyen
dc.check.opt-outYesen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.contributor.advisorMolloy, Michael G.en
dc.contributor.advisorShanahan, Fergusen
dc.contributor.authorCronin, Owen
dc.contributor.funderIrish Centre for Arthritis Research and Education (ICARE)en
dc.date.accessioned2018-04-17T10:39:47Z
dc.date.issued2018
dc.date.submitted2018
dc.description.abstractIntroduction: Promotion of regular physical activity is a critical tool in the fight against chronic disease. However, our knowledge of the interplay between host organ systems and exercise is limited, preventing us from harnessing the full potential exercise promises in the prevention and treatment of chronic disease. Methods: To maximize our ability to use exercise-related adaptions for health improvement, we focussed on practical and translational areas of Exercise Medicine, centred on 1) the antiinflammatory effects of exercise and 2) the impact of exercise and associated diet on the intestinal microbiota. To do so we used a combination of systematic review, randomized control trials, and prospective observational analyses. Results: Relating to the impact of exercise on the gut microbiome, this work suggests that favourable microbial profiles are evident in the elite athlete in comparison to healthy controls. It is apparent that short-term increases in physical activity are not sufficient to induce major changes in physically inactive individuals. Furthermore, we unearth a relationship between whey protein intake, often used as a dietary adjunct to exercise in recreational and elite sport, and altered diversity of the gut virome. We demonstrate that short-term combined cardiorespiratory and resistance exercise does not lead to significant reductions in the circulating inflammatory biomarker profiles of sedentary individuals or patients with stable inflammatory bowel disease. In contrast, we show that periods of intense exercise, such as those performed during pre-season training in elite sport, alters important components of the innate immune response. Conclusions: Implications of the findings in this thesis are far-reaching and have translational learning points for athletes, patients and physically inactive populations. The work performed underlines the need for further research including the effects of long-term fitness improvement on the gut microbiota and the effects of exercise on disease activity in patients with Inflammatory Bowel Disease.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCronin, O. 2018. Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/5789
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2018, Owen Cronin.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectMicrobiomeen
dc.subjectExerciseen
dc.subjectInflammationen
dc.subjectCytokinesen
dc.subjectPhysical activityen
dc.thesis.opt-outtrue
dc.titlePhysical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokinesen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoral Degree (Structured)en
dc.type.qualificationnamePhD (Medicine and Health)en
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
CroninOC_PhD2018.pdf
Size:
49.71 KB
Format:
Adobe Portable Document Format
Description:
Abstract
License bundle
Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
license.txt
Size:
5.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Loading...
Thumbnail Image
Name:
Owen Cronin.pdf
Size:
32.23 KB
Format:
Adobe Portable Document Format
Description:
Opt-out form