dc.check.embargoformat	Not applicable	en
dc.check.info	No embargo required	en
dc.check.opt-out	Not applicable	en
dc.check.reason	No embargo required	en
dc.check.type	No Embargo Required
dc.contributor.advisor	Whelton, Helen	en
dc.contributor.advisor	Sheehan, David	en
dc.contributor.author	Harding, Máiréad
dc.contributor.funder	GSK Consumer Healthcare (UK)	en
dc.contributor.funder	Health Research Board	en
dc.date.accessioned	2016-06-29T14:51:41Z
dc.date.available	2016-06-29T14:51:41Z
dc.date.issued	2015
dc.date.submitted	2015
dc.description.abstract	Aim: To investigate the characteristics, development and determinants of toothwear among Irish schoolchildren. Methods: A cross-sectional (examination at 16-years-old) and longitudinal (examinations at 5-,12-,14-years) study were conducted. Two indices were used to measure toothwear, children/parents completed a demographic profile and questionnaire on oral hygiene and dietary practices, health, and lifestyle in both studies. Saliva was collected from consenting 16-year-olds. The explanatory variables for the cross-sectional and longitudinal study were derived from children/parents responses. Differences in salivary profiles were determined for subsets; the protein concentration was determined with Bradford protein assay and protein carbonyl concentration (a protein oxidation marker) was determined spectrophotometrically. Gel-electrophoresis and mass spectrometry determined proteins and ion chromatography inorganic ions. Statistical significance was accepted at p<0.05. Results: At 16-years-old the prevalence of toothwear with dentine visible was 44%. No difference in salivary flow rates existed. In unstimulated saliva a higher mean, protein carbonyl (p<0.0001) and total calcium concentration (p<0.002) existed for the group with moderate toothwear. In stimulated saliva the moderate toothwear group had a lower mean protein concentration(p<0.0001). The 2-DE protein spots prepared for a sub-group differed between those with toothwear and without. Mass spectrometry, identified one of the different proteins as IgA. For 16-year-olds, the self-reported factors indicated that brushing after breakfast was associated with lower toothwear scores(p<0.03). Nail-biting, being asthmatic or reporting a dry mouth were associated with higher toothwear scores(all p<0.05). Eating an apple daily or less was associated with less toothwear(p<0.002). In the longitudinal study toothwear into dentine at age five or 12-years was associated with more toothwear at age 14(all p<0.05). Discussion: The results illustrate the multifactorial aetiology of toothwear. The biochemical and physical correlates of saliva with toothwear requires further research. Conclusion: The impact of previous toothwear, salivary, dietary and personal factors on toothwear in the early permanent dentition is demonstrated.	en
dc.description.sponsorship	Health Research Board (HRB Project grant PR/2005/267)	en
dc.description.status	Not peer reviewed	en
dc.description.version	Accepted Version
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Harding, M. A. 2015. Tooth wear in Irish teenagers: a laboratory and epidemiological study. PhD Thesis, University College Cork.	en
dc.identifier.uri	https://hdl.handle.net/10468/2813
dc.language.iso	en	en
dc.publisher	University College Cork	en
dc.rights	© 2015, Máiréad A. Harding	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/	en
dc.subject	Epidemiological	en
dc.subject	Tooth wear	en
dc.subject	Diet	en
dc.subject	Index	en
dc.subject	Saliva	en
dc.thesis.opt-out	false
dc.title	Tooth wear in Irish teenagers: a laboratory and epidemiological study	en
dc.type	Doctoral thesis	en
dc.type.qualificationlevel	Doctoral	en
dc.type.qualificationname	PhD (Dentistry)	en
ucc.workflow.supervisor	d.sheehan@ucc.ie

Tooth wear in Irish teenagers: a laboratory and epidemiological study

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