Rapid determination of NSAIDs by capillary and microchip electrophoresis with capacitively coupled contactless conductivity detection in wastewater

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dc.contributor.authorAlatawi, Hanan
dc.contributor.authorHogan, Anna
dc.contributor.authorAlbalawi, Ibtihaj
dc.contributor.authorO'Sullivan-Carroll, Emma
dc.contributor.authorAlsefri, Samia
dc.contributor.authorWang, Yineng
dc.contributor.authorMoore, Eric
dc.contributor.funderSaudi Arabian Cultural Bureauen
dc.date.accessioned2023-02-28T10:32:45Z
dc.date.available2023-02-28T10:32:45Z
dc.date.issued2022-10
dc.date.updated2023-02-27T15:58:45Z
dc.description.abstractA simple, rapid method using CE and microchip electrophoresis with (CD)-D-4 has been developed for the separation of four nonsteroidal anti-inflammatory drugs (NSAIDs) in the environmental sample. The investigated compounds were ibuprofen (IB), ketoprofen (KET), acetylsalicylic acid (ASA), and diclofenac sodium (DIC). In the present study, we applied for the first time microchip electrophoresis with (CD)-D-4 detection to the separation and detection of ASA, IB, DIC, and KET in the wastewater matrix. Under optimum conditions, the four NSAIDs compounds could be well separated in less than 1 min in a BGE composed of 20 mM His/15 mM Tris, pH 8.6, 2 mM hydroxypropyl-beta-cyclodextrin, and 10% methanol (v/v) at a separation voltage of 1000-1200 V. The proposed method showed excellent repeatability, good sensitivity (LODs ranging between 0.156 and 0.6 mg/L), low cost, high sample throughputs, portable instrumentation for mobile deployment, and extremely lower reagent and sample consumption. The developed method was applied to the analysis of pharmaceuticals in wastewater samples with satisfactory recoveries ranging from 62.5% to 118%.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlatawi, H., Hogan, A., Albalawi, I., O’Sullivan‐Carroll, E., Alsefri, S., Wang, Y. and Moore, E. (2022) ‘Rapid determination of NSAIDs by capillary and microchip electrophoresis with capacitively coupled contactless conductivity detection in wastewater’, Electrophoresis, 43(20), pp. 1944–1952. doi: 10.1002/elps.202200116en
dc.identifier.doi10.1002/elps.202200116en
dc.identifier.endpage1952en
dc.identifier.issn0173-0835
dc.identifier.issued20en
dc.identifier.journaltitleElectrophoresisen
dc.identifier.startpage1944en
dc.identifier.urihttps://hdl.handle.net/10468/14248
dc.identifier.volume43en
dc.language.isoenen
dc.publisherJohn Wiley and Sons Inc.en
dc.rights© 2022 The Authors. Electrophores is published by Wiley-VCH GmbH. This is an open access article under the terms of theCreative Commons Attribution-NonCommercialLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectNonsteroidal antiinflammatory drugsen
dc.subjectPersonal-care productsen
dc.subjectLiquid-chromatographyen
dc.subjectAquatic environmenten
dc.subjectUV detectionen
dc.subjectFateen
dc.subjectPharmaceuticalsen
dc.subjectPreconcentrationen
dc.subjectPollutantsen
dc.subjectSeparationen
dc.titleRapid determination of NSAIDs by capillary and microchip electrophoresis with capacitively coupled contactless conductivity detection in wastewateren
dc.typeArticle (peer-reviewed)en
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