Flexible electrode based on gold nanoparticles and reduced graphene oxide for uric acid detection using linear sweep voltammetry

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dc.contributor.authorMazzara, Francesca
dc.contributor.authorPatella, Bernardo
dc.contributor.authorGanci, Fabrizio
dc.contributor.authorO'Riordan, Alan
dc.contributor.authorAiello, Giuseppe
dc.contributor.authorTorino, Claudia
dc.contributor.authorVilasi, Antonio
dc.contributor.authorSunseri, Carmelo
dc.contributor.authorInguanta, Rosalinda
dc.contributor.funderUniversità degli Studi di Palermoen
dc.contributor.funderConsiglio Nazionale delle Ricercheen
dc.contributor.funderMinistero dello Sviluppo Economicoen
dc.date.accessioned2021-07-16T11:13:38Z
dc.date.available2021-07-16T11:13:38Z
dc.date.issued2021
dc.date.updated2021-07-15T10:53:10Z
dc.description.abstractIn this work, an electrochemical sensor for uric acid determination is shown with a preliminary study for its validation in real samples (milk and urine). Uric acid can be electrochemically oxidized in aqueous solutions and thus it is possible to obtain electrochemical sensors for this chemical by means of this electrooxidation reaction. Indium tin oxide coated on flexible polyethylene terephthalate substrate, modified with reduced graphene oxide and gold nanoparticles by co-electrodeposition, was used. Electrodeposition was performed at -0.8V vs SCE for 200 s. All samples were characterized by electron scan microscopy and electron diffraction spectroscopy. A careful investigation on the effect of pH was performed to understand its influence on uric acid oxidation. The detection of uric acid was using the linear sweep voltammetry. Results show that the peak current increases linearly with uric acid concentration from 10 to 1000 μM with a limit of detection of about 7.1 μM. The sensor shows high selectivity towards different interferents that can be found in the milk and urine matrix, such as chloride, calcium, sodium and ammonium ions. To prove the applicability of the proposed sensor, uric acid was quantified in real milk and urine samples with excellent results comparable to those of conventional techniques.en
dc.description.sponsorshipMinistero dello Sviluppo Economico (PATCHES – Patient-Centered HEalthcare System for neurodegenerative diseases” n. 610, Ministero dello Sviluppo Economico, Accordi per l’innovazione, Programma operativo nazionale «Imprese e competitività» 2014-2020 FESR e del Fondo per la crescita sostenibile)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMazzara, F., Patella, B., Ganci, F., O'Riordan, A., Aiello, G., Torino, C.,Vilasi, A., Sunseri, C. and Inguanta, R. (2021) 'Flexible electrode based on gold nanoparticles and reduced graphene oxide for uric acid detection using linear sweep voltammetry', Chemical Engineering Transactions, 87, pp. 421-426. doi: 10.3303/CET2187071en
dc.identifier.doi10.3303/CET2187071en
dc.identifier.endpage426en
dc.identifier.issn978-88-95608-85-3
dc.identifier.journaltitleChemical Engineering Transactionsen
dc.identifier.startpage421en
dc.identifier.urihttps://hdl.handle.net/10468/11572
dc.identifier.volume87en
dc.language.isoenen
dc.publisherItalian Association of Chemical Engineeringen
dc.rights© 2021, AIDIC Servizi S.r.l.en
dc.subjectElectrochemical sensoren
dc.subjectUric aciden
dc.subjectMilken
dc.subjectUrineen
dc.titleFlexible electrode based on gold nanoparticles and reduced graphene oxide for uric acid detection using linear sweep voltammetryen
dc.typeArticle (peer-reviewed)en
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