Renal failure and the neural control of the kidney

dc.check.embargoformatE-thesis on CORA onlyen
dc.check.entireThesisEntire Thesis Restricted
dc.check.opt-outNot applicableen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.contributor.advisorJohns, Edward J.en
dc.contributor.authorGoulding, Niamh E.
dc.contributor.funderHealth Research Boarden
dc.description.abstractRenal failure (RF) is associated with an over activation of the sympathetic nervous system. The aim of this thesis was to investigate the hypothesis that as the kidney progresses into RF there is an inappropriate and sustained activation of renal afferent nerves which results in a dysregulation of basal RSNA and reflexly controlled RSNA by the high and low pressure baroreceptors. Baroreflex gain curves for both RSNA and HR were generated in control and RF rats. This study clearly showed a blunted high-pressure baroreflex in RF rats, an impairment which was almost completely corrected by bilateral renal denervation. The integrity of the low-pressure cardiopulmonary receptors to inhibit RSNA was investigated using acute saline volume. Again, a blunted reflex sympatho-inhibition of RSNA was observed, which was corrected by renal denervation. Finally a functional study to examine how the renal excretory response to volume expansion differed in RF was carried out. This study revealed an impairment of the low-pressure baroreflex control of the sympathetic outflow. The result of these studies suggest that cisplatin induced RF initiates a neural signal from within the kidney, which over rides the normal reflex regulation of RSNA by the high and low – pressure baroreceptors and that this impairment in function can be normalised by renal denervation. This raises further questions as to the mechanisms involved in the afferent over activation arising from the diseased kidneys.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.identifier.citationGoulding, N. E. 2013. Renal failure and the neural control of the kidney. PhD Thesis, University College Cork.en
dc.publisherUniversity College Corken
dc.rights© 2013, Niamh E. Goulding.en
dc.subjectRenal failureen
dc.subjectRenal denervationen
dc.subjectCure for hypertensionen
dc.subjectDrug resistant hypertensionen
dc.subjectHigh blood pressureen
dc.subjectRenal functionen
dc.subjectRenal nervesen
dc.subject.lcshRenal hypertensionen
dc.titleRenal failure and the neural control of the kidneyen
dc.typeDoctoral thesisen
dc.type.qualificationnamePhD (Science)en
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