Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

Courtney, Eimear; Mulcahy, James; Hickey, Aobha; Mertz, Julia; Light, Mark; Marder, Todd B.; McGlacken, Gerard P.

Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

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Files

regioselective-iridium-catalyzed-c_7_-h-borylation-of-free-n-h-6-fluoroquinolones.pdf(3.44 MB)

Date

2026-04-23

Authors

Courtney, Eimear

Mulcahy, James

Hickey, Aobha

Mertz, Julia

Light, Mark

Marder, Todd B.

McGlacken, Gerard P.

Publisher

American Chemical Society

Published Version

10.1021/acsomega.5c11604

Abstract

Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C–H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position.

Keywords

Iridium-catalyzed C−H borylation strategy for unprotected NH 6-fluoroquinolones , [Chemistry]

Citation

Courtney, E, Mulcahy, J, Hickey, A, Mertz, J, Light, M, Marder, T B & McGlacken, G P 2026, 'Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones', ACS Omega, vol. 11, no. 17, pp. 25149-25155. https://doi.org/10.1021/acsomega.5c11604