Gut microbial composition varies with host metabolic phenotype in juvenile Atlantic salmon

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dc.contributor.authorLindsay, Elle C.
dc.contributor.authorBarcan, Alexandru S.
dc.contributor.authorMetcalfe, Neil B.
dc.contributor.authorBryce, Abby L.E.
dc.contributor.authorMcGinnity, Philip
dc.contributor.authorLlewellyn, Martin S.
dc.contributor.authorCheaib, Bachar A.
dc.contributor.funderBiotechnology and Biological Sciences Research Council, BB/Y012437/1-BB/T016280/1-BB/N024028/1-BB/P001203/1
dc.contributor.funderScience Foundation Ireland (SFI)
dc.contributor.funderMarine Institute Ireland
dc.contributor.funderDepartment for the Economy, Belfast, Northern Ireland, SFI/15/IA/3028
dc.contributor.funderEuropean Research Council, 834653
dc.contributor.funderScience Foundation Ireland(SFI), 16/BBSRC/3316
dc.contributor.funderUniversity of Glasgow
dc.date.accessioned2026-09-21T11:58:01Z
dc.date.available2026-09-21T11:58:01Z
dc.date.issued2026-03-25
dc.description.abstractStandard metabolic rate (SMR) influences growth, behaviour and energy use in fish, yet its relationship with gut microbiota remains unclear. Here, we combined physiological measurements with 16S rRNA sequencing of foregut and hindgut tissue to test whether gut microbial communities differ with metabolic phenotype in juvenile Atlantic salmon. High-SMR fish showed greater growth efficiency and lower body water content than low-SMR fish, indicating higher fat levels. In contrast, microbial differences were most evident in the foregut, where low-SMR fish exhibited significantly higher alpha diversity. Microbial beta-diversity analyses revealed clear segregation among metabolic groups, and distance-based redundancy analysis showed that both SMR and body mass strongly explained variation in foregut microbial composition. Correlation analysis identified a negative association between SMR and members of the Rhodobacteraceae family, which were consistently more abundant in the foregut of low-SMR fish. Together, these findings indicate that the metabolic phenotype is associated with distinct patterns of energy utilisation and gut microbiota composition, suggesting that foregut microbial communities may contribute to individual differences in metabolic strategy.en
dc.description.sponsorshipBiotechnology and Biological Science Research Council|BB/T016280/1
dc.description.sponsorshipBiotechnology and Biological Science Research Council|BB/N024028/1
dc.description.sponsorshipBiotechnology and Biological Science Research Council|BB/P001203/1
dc.description.sponsorshipBiotechnology and Biological Science Research Council|BB/Y012437/1
dc.description.sponsorshipScience Foundation Ireland
dc.description.sponsorshipMarine Institute Ireland
dc.description.sponsorshipDepartment for the Economy, Belfast, Northern Ireland|SFI/15/IA/3028
dc.description.sponsorshipEuropean Research Council|834653
dc.description.sponsorshipScience Foundation Ireland|16/BBSRC/3316
dc.description.versionPublished Version
dc.format.extent17
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidjeb251523
dc.identifier.authororcidLindsay, Elle C.
dc.identifier.authororcidBarcan, Alexandru S.
dc.identifier.authororcidMetcalfe, Neil B.
dc.identifier.authororcidBryce, Abby L.E.
dc.identifier.authororcidMcGinnity, Philip§0000-0001-5199-5632
dc.identifier.authororcidLlewellyn, Martin S.
dc.identifier.authororcidCheaib, Bachar A.
dc.identifier.citationLindsay, E C, Barcan, A S, Metcalfe, N B, Bryce, A L E, McGinnity, P, Llewellyn, M S & Cheaib, B A 2026, 'Gut microbial composition varies with host metabolic phenotype in juvenile Atlantic salmon', Journal of Experimental Biology, vol. 229, no. 9, jeb251523, pp. 1-17. https://doi.org/10.1242/jeb.251523
dc.identifier.doi10.1242/jeb.251523
dc.identifier.endpage17
dc.identifier.issn0022-0949
dc.identifier.issued9
dc.identifier.journaltitleJournal of Experimental Biology
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/19301
dc.identifier.volume229
dc.language.isoen
dc.publisherCompany of Biologists Ltd
dc.relation.urihttps://www.scopus.com/pages/publications/105038851303
dc.rights© 2026, authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectGrowth efficiency
dc.subjectGut microbiota
dc.subjectRhodobacteraceae
dc.subjectSalmo salar
dc.subjectStandard metabolic rate
dc.subject[BEES]
dc.titleGut microbial composition varies with host metabolic phenotype in juvenile Atlantic salmonen
dc.typeArticle (peer-reviewed)
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