Interplay between competitive and cooperative interactions in a three-player pathogen system

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dc.contributor.authorPinotti, Francesco
dc.contributor.authorGhanbarnejad, Fakhteh
dc.contributor.authorHövel, Philipp
dc.contributor.authorPoletto, Chiara
dc.contributor.funderUniversité Sorbonne Paris Citéen
dc.contributor.funderDeutscher Akademischer Austauschdiensten
dc.contributor.funderCampus Franceen
dc.contributor.funderDeutsche Forschungsgemeinschaften
dc.contributor.funderMunicipality of Parisen
dc.date.accessioned2020-04-28T12:09:38Z
dc.date.available2020-04-28T12:09:38Z
dc.date.issued2020-01-22
dc.date.updated2020-04-28T07:59:17Z
dc.description.abstractIn ecological systems, heterogeneous interactions between pathogens take place simultaneously. This occurs, for instance, when two pathogens cooperate, while at the same time, multiple strains of these pathogens co-circulate and compete. Notable examples include the cooperation of human immunodeficiency virus with antibiotic-resistant and susceptible strains of tuberculosis or some respiratory infections with Streptococcus pneumoniae strains. Models focusing on competition or cooperation separately fail to describe how these concurrent interactions shape the epidemiology of such diseases. We studied this problem considering two cooperating pathogens, where one pathogen is further structured in two strains. The spreading follows a susceptible-infected-susceptible process and the strains differ in transmissibility and extent of cooperation with the other pathogen. We combined a mean-field stability analysis with stochastic simulations on networks considering both well-mixed and structured populations. We observed the emergence of a complex phase diagram, where the conditions for the less transmissible, but more cooperative strain to dominate are non-trivial, e.g. non-monotonic boundaries and bistability. Coupled with community structure, the presence of the cooperative pathogen enables the coexistence between strains by breaking the spatial symmetry and dynamically creating different ecological niches. These results shed light on ecological mechanisms that may impact the epidemiology of diseases of public health concern.en
dc.description.sponsorshipUniversité Sorbonne Paris Cité (Pierre Louis Doctoral School of Public Health); Deutscher Akademischer Austauschdienst (German Academic Exchange Service (DAAD) within the PPP-PROCOPE framework (grant no.57389088); Campus France (Partenariats Hubert Curien within the PPP-PROCOPE (grant no. 35473TK)); Deutsche Forschungsgemeinschaft (DFG) under the grant GH 176/1-1 (idonate project: 345463468), Collaborative Research Center 910 (grant no. SFB910)); Municipality of Paris (through the program Emergence(s))en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid190305en
dc.identifier.citationPinotti, F., Ghanbarnejad, F., Hövel, P. and Poletto, C. (2020) 'Interplay between competitive and cooperative interactions in a three-player pathogen system', Royal Society Open Science, 7, 190305 (14 pp). doi: 10.1098/rsos.190305en
dc.identifier.doi10.1098/rsos.190305en
dc.identifier.endpage14en
dc.identifier.issn2054-5703
dc.identifier.journaltitleRoyal Society Open Scienceen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9884
dc.identifier.volume7en
dc.language.isoenen
dc.publisherRoyal Societyen
dc.relation.urihttps://royalsocietypublishing.org/doi/pdf/10.1098/rsos.190305
dc.rights© 2020 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDisease ecologyen
dc.subjectComplex networksen
dc.subjectMultipathogen systemsen
dc.subjectEpidemic spreadingen
dc.titleInterplay between competitive and cooperative interactions in a three-player pathogen systemen
dc.typeArticle (peer-reviewed)en
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