Impact of vitamin D on gene expression in Atlantic salmon skin

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dc.contributor.authorTaylor, Lewis D.
dc.contributor.authorGorman, Courtney E.
dc.contributor.authorEgan, Fintan
dc.contributor.authorRuane, Neil M.
dc.contributor.authorMcGinnity, Philip
dc.contributor.authorHulsey, C. Darrin
dc.contributor.funderScience Foundation Ireland (SFI)
dc.date.accessioned2026-08-19T09:32:01Z
dc.date.available2026-08-19T09:32:01Z
dc.date.issued2026-05-18
dc.description© 2026 Taylor et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractVitamin D is a crucial micronutrient for vertebrate health that affects musculoskeletal function and likely modulates immune responses in tissues such as the skin. Infectious diseases are a critical concern in Atlantic salmon aquaculture due to the potential economic impact of stock losses, risks to fish welfare, and environmental sustainability. Since the skin is the first line of immunological defence, its ability to mediate host-pathogen interactions may be influenced by dietary vitamin D. This study examined the transcriptomic response of salmon skin after six months of dietary vitamin D supplementation, with an emphasis on immune-related gene expression. A total of 151 differentially expressed genes were identified, 27 of which are linked to inflammation, antigen presentation, and both innate and adaptive immunity. These results indicate that vitamin D could modulate cutaneous immune responses by reducing inflammation and enhancing innate defences, potentially improving resistance to many skin-associated salmon pathogens.en
dc.description.sponsorshipScience Foundation Ireland Frontiers|21/FFP-P/10171|SFI/15/IA/3028
dc.format.extent14
dc.format.extent919869
dc.identifier.articleide0349197
dc.identifier.authororcidTaylor, Lewis D.
dc.identifier.authororcidGorman, Courtney E.
dc.identifier.authororcidEgan, Fintan
dc.identifier.authororcidRuane, Neil M.
dc.identifier.authororcidMcGinnity, Philip§0000-0001-5199-5632
dc.identifier.authororcidHulsey, C. Darrin
dc.identifier.citationTaylor, L D, Gorman, C E, Egan, F, Ruane, N M, McGinnity, P & Hulsey, C D 2026, 'Impact of vitamin D on gene expression in Atlantic salmon skin', PLOS ONE, vol. 21, no. 5, e0349197, pp. 1-14. https://doi.org/10.1371/journal.pone.0349197
dc.identifier.doi10.1371/journal.pone.0349197
dc.identifier.endpage14
dc.identifier.issn1932-6203
dc.identifier.issued5
dc.identifier.journaltitlePLOS ONE
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/19128
dc.identifier.urlhttps://www.scopus.com/pages/publications/105039053616
dc.identifier.volume21
dc.language.isoeng
dc.rightscc_by
dc.subjectSDG 14 - Life Below Water
dc.subjectMicronutrient
dc.subjectVertebrate health
dc.subjectMusculoskeletal function
dc.subject[BEES]
dc.subjectMultidisciplinary
dc.titleImpact of vitamin D on gene expression in Atlantic salmon skinen
dc.typeArticle (Peer reviewed)
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