Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals

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dc.check.date2029-12-31
dc.contributor.advisorMoore, Anne
dc.contributor.advisorVucen, Sonja
dc.contributor.authorWilkstein, Katerinaen
dc.contributor.funderHEA AIVRTen
dc.date.accessioned2024-09-30T17:22:36Z
dc.date.available2024-09-30T17:22:36Z
dc.date.issued2024en
dc.date.submitted2024
dc.description.abstractDissolvable microneedles are an intradermal drug delivery technology with exciting potential for widespread distribution of minimally invasive, self-administered medicines and vaccines. The most popular manufacturing method for medical dissolvable microneedles is micromoulding, a process which can have drawbacks of low material efficiency and high regulatory requirements. The UCC-patented “ImmuPatch” process is a micromoulding method which significantly improves on the material efficiency of traditional micromoulding. In this study, a specific method based upon the ImmuPatch process was developed for aseptic manual fabrication of two-layered dissolvable microneedles capable of incorporating at 2 μg protein dose. The developed method was not ideal, with high variability in the patches produced and significant challenges in verifying the protein dose. Fabrication of dissolvable microneedles is well positioned for the application of automation methods. One proposed option for the automation of dissolvable microneedle manufacture is additive manufacturing, which in addition to automation has the advantage of eliminating the regulatory challenges associated with micromoulding. A systematic literature review of methods applying additive manufacturing to the fabrication of solid dosage formats was conducted and identified processing parameters and format properties associated with different technologies. Additive manufacturing has been applied to micromould-free dissolvable microneedle fabrication in limited examples and should be explored further.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWilkstein, K. 2024. Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals. MRes Thesis, University College Cork.
dc.identifier.endpage165
dc.identifier.urihttps://hdl.handle.net/10468/16467
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2024, Katerina Wilkstein.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicroneedles
dc.subjectVaccines
dc.subjectVaccine
dc.subjectThree-dimensional printing
dc.subject3d printing
dc.subjectAdditive manufacturing
dc.subjectProcess design
dc.subjectProcess scale up
dc.subjectErgonomic safety
dc.subjectProcess optimisation
dc.subjectPharmaceutical process
dc.titleDissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals
dc.typeMasters thesis (Research)en
dc.type.qualificationlevelMastersen
dc.type.qualificationnameMRes - Master of Researchen
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