Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

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dc.contributor.authorWalther, Andreas
dc.contributor.authorRippe, Lars
dc.contributor.authorWang, Lihong V.
dc.contributor.authorAndersson-Engels, Stefan
dc.contributor.authorKröll, Stefan
dc.contributor.funderVetenskapsrĂĄdet
dc.contributor.funderFifth Framework Programme
dc.contributor.funderKnut och Alice Wallenbergs Stiftelse
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-06-15T11:47:18Z
dc.date.available2018-06-15T11:47:18Z
dc.date.issued2017
dc.description.abstractDespite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrastto- noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics. (C) 2017 Optical Society of Americaen
dc.description.sponsorshipFifth Framework Programme (Lund laser centre)en
dc.description.statusPeer reviewed
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationWalther, A., Rippe, L., Wang, L. V., Andersson-Engels, S. and Kröll, S. (2017) 'Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)', Biomedical Optics Express, 8(10), pp. 4523-4536. doi: 10.1364/BOE.8.004523en
dc.identifier.doi10.1364/BOE.8.004523
dc.identifier.endpage4536
dc.identifier.issn2156-7085
dc.identifier.issued10
dc.identifier.journaltitleBiomedical Optics Expressen
dc.identifier.startpage4523
dc.identifier.urihttps://hdl.handle.net/10468/6352
dc.identifier.volume8
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.relation.urihttps://www.osapublishing.org/boe/abstract.cfm?uri=boe-8-10-4523
dc.rights© 2018, Optical Society of America under the terms of the OSA Open Access Publishing Agreementen
dc.rights.urihttps://www.osapublishing.org/library/license_v1.cfm#VOR-OA
dc.subjectBiological tissuesen
dc.subjectSpectroscopyen
dc.subjectModulationen
dc.subjectAbsorptionen
dc.subjectDependenceen
dc.subjectFrequencyen
dc.subjectLighten
dc.titleAnalysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)en
dc.typeArticle (peer-reviewed)en
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