UNCCER: unified network for cancer classification and efficient representation using microarray data
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Date
2024-12-26
Authors
Younis, Haseeb
Brahmi, Imane
Byrne, Jonathan
Minghim, Rosane
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Publisher
Institute of Electrical and Electronics Engineers (IEEE)
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Abstract
In recent years, there has been a significant advance in the use of machine learning (ML) techniques to extract gene expression data from microarray databases, particularly in cancer-related research. There no unified method for classifying cancer microarray data, even after ML adoption. Due to the high dimensionality of microarray data, it is difficult to extract the relevant features and provide insights that can be helpful in identifying cancer types and stages. In this paper, we propose a Unified Network for Cancer Classification and Efficient Representation (UNCCER) using Deep Learning (DL) on cancer microarray data. To implement this methodology, we employed a microarray database (CuMiDa) that has 78 carefully curated datasets for different types of cancers. Our single model has the capability to learn the patterns, cluster instances into their corresponding classes, and classify the cancer. We also used the Uniform Manifold Approximation and Projection (UMAP) to visualise, in low dimension, the instance separation both on original data and transformed data by our methodology. Using the proposed methodology, we achieved average 94% average accuracy, precision, recall, F1 Score, and 91% G-Mean.
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Keywords
Deep learning , Manifolds , Databases , Data visualization , Predictive models , Feature extraction , Data models , Data mining , Gene expression , Cancer
Citation
Younis, H., Brahmi, H.I., Byrne, J. and Minghim, R. (2024) ‘UNCCER: unified network for cancer classification and efficient representation using microarray data’, 2024 18th International Conference on Open Source Systems and Technologies (ICOSST), Lahore, Pakistan, 26-27 December 2024, pp. 1–6. https://doi.org/10.1109/ICOSST64562.2024.10871147
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